Introduction: Adequate bowel preparation is often difficult to achieve in hospitalized patients because of advanced age, comorbidities, immobility, and concurrent medications. This multicenter randomized INTERPRET trial compared 1-L, 2-L, and 4-L polyethylene glycol (PEG) regimens to determine the optimal bowel preparation for elective inpatient colonoscopy.
Introduction:
Adequate bowel preparation is often difficult to achieve in hospitalized patients because of advanced age, comorbidities, immobility, and concurrent medications. This multicenter randomized INTERPRET trial compared 1-L, 2-L, and 4-L polyethylene glycol (PEG) regimens to determine the optimal bowel preparation for elective inpatient colonoscopy.
Why was this study needed?
Results:
Clinical Impact:
This landmark randomized trial challenges the routine use of high-volume bowel preparation in stable hospitalized patients. A split-dose 1-L PEG regimen appears to offer an excellent balance between efficacy, patient acceptance, and procedural quality, although caution remains necessary in patients with severe constipation, advanced kidney disease, or those requiring urgent colonoscopy.
Bottom Line:
For stable inpatients undergoing elective colonoscopy, 1-L PEG plus ascorbate provides the best balance of bowel cleansing quality and patient tolerability. These findings are likely to influence future bowel preparation guidelines and support broader adoption of low-volume regimens in hospitalized patients.
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