Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of hematologic malignancies but has achieved limited success in solid tumors such as pancreatic cancer. Major barriers...
Adipose tissue is no longer viewed simply as a fat storage organ; it is now recognized as a highly active endocrine and neuro-regulatory organ that coordinates whole-body metabolism....
Introduction: Despite major advances in lipid-lowering therapy, many patients continue to experience residual cardiovascular risk, particularly those with elevated triglyceride-rich lipoproteins and mixed dyslipidemia. Angiopoietin-like protein 3 (ANGPTL3)...
Cancer cells constantly adapt to inflammatory stress generated by the immune system, particularly during immune checkpoint inhibitor therapy. This study explored whether inflammatory cytokines such as interferon-γ (IFNγ),...
Introduction: The colorectal cancer (CRC) microbiome has emerged as a key factor influencing tumor development, progression, and response to treatment. Among microbial species implicated in CRC, Fusobacterium nucleatum...
Cancer cells constantly adapt to inflammatory stress generated by the immune system, particularly during immune checkpoint inhibitor therapy. This study explored whether inflammatory cytokines such as interferon-γ (IFNγ),...
Tertiary lymphoid structures are local immune hubs within tumors, but this study shows that their mere presence is not enough; their maturation, location, and cellular organization determine biological...
CLDN18.2 is emerging as a therapeutic target in gastrointestinal cancers, but its benefit in pancreatic ductal adenocarcinoma has been limited. This study identifies a key resistance mechanism: KRAS...
The oral cavity contains the second largest microbial ecosystem in the human body and acts as a major interface between the external environment and multiple organ systems. This...
This translational study investigated whether exercise-induced changes in gut microbiota contribute to the metabolic benefits observed after Roux-en-Y gastric bypass surgery. Thirty-two women undergoing bariatric surgery were randomized...
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