Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: Chronic inflammation is the principal driver of colitis-associated cancer (CAC) in patients with long-standing ulcerative colitis (UC). Although the intestinal microbiome has long been implicated in colorectal...
Introduction: Introduction: Claudin 18.2 (CLDN18.2) has emerged as an important therapeutic target in gastrointestinal malignancies, with encouraging results in gastric and gastroesophageal cancers. Its expression in pancreatic ductal...
Introduction: Esophageal Adenocarcinoma is an aggressive malignancy strongly associated with chronic gastroesophageal reflux disease and exposure to acidic bile reflux. Despite advances in multimodal therapy, chemotherapy resistance remains...
Introduction Hypercholesterolemia remains a major driver of atherosclerotic cardiovascular disease despite the availability of statins, PCSK9 inhibitors and RNA-based therapies. Lifelong treatment adherence and incomplete LDL reduction continue...
Introduction Liver development during childhood involves dynamic metabolic, immune and stromal maturation processes that differ substantially from adult liver biology. However, most hepatic single-cell reference atlases and mechanistic...
Introduction Chronic Pancreatitis is a well-established risk factor for Pancreatic Ductal Adenocarcinoma, particularly in hereditary pancreatitis syndromes where lifetime cancer risk is markedly elevated. However, the biologic mechanisms...
Introduction Hypoxia-Inducible Factor 1-alpha is a master regulator of cellular adaptation to hypoxia, coordinating metabolic reprogramming, angiogenesis and stress responses. Although transient HIF-1α activation is protective during acute...
Introduction Programmed Cell Death Protein 1 blockade has revolutionized cancer immunotherapy, yet the precise spatial and temporal mechanisms by which PD-1 suppresses T-cell activation remain incompletely understood. Although...
Introduction Autophagy is a highly conserved cellular homeostatic mechanism that enables recycling of intracellular components, removal of damaged organelles and adaptation to metabolic stress. In cancer biology, autophagy...
Introduction Liver Fibrosis results from persistent hepatic injury, chronic inflammation and activation of hepatic stellate cells (HSCs). Chemokine-mediated immune recruitment is central to fibrogenesis, yet many inflammatory pathways...
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