Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction Germline CTNNA1 variants have emerged as an important cause of hereditary diffuse gastric cancer (HDGC), yet their clinical penetrance, disease spectrum and biological mechanisms have remained poorly...
Introduction Microbial dysbiosis plays a pivotal role in the pathogenesis of ulcerative colitis (UC) and inflammation-associated colorectal cancer. Among emerging pathobionts, Parasutterella excrementihominis has recently gained attention because...
Introduction Psychosocial stressors such as loneliness, chronic stress and social disadvantage are increasingly recognized as major contributors to cardiometabolic disease. Natural killer cell activity plays a central role...
Introduction Metabolic dysfunction-associated steatotic liver disease affects nearly one-third of the global population and spans a disease spectrum from steatosis to steatohepatitis, fibrosis and cirrhosis. Despite major advances...
Introduction Alzheimer’s disease (AD) is increasingly recognized as a multifactorial disorder driven by complex interactions among genetic susceptibility, metabolic dysfunction, neuroinflammation and environmental exposures. With currently available pharmacotherapies...
Introduction Adoptive cellular immunotherapies have transformed cancer treatment, but current strategies generally require ex vivo cell engineering, manufacturing complexity and individualized processing. The ability to selectively reprogram cytotoxic...
Introduction Intestinal fibrosis is a major complication of Crohn’s disease, frequently leading to strictures, bowel obstruction and surgery. While fibroblast activation is central to fibrogenesis, the metabolic pathways...
Introduction Regulatory T cells (Tregs) are central mediators of immune tolerance and immune homeostasis. In cancer, however, these same suppressive functions are frequently exploited by tumors to evade...
Introduction Metformin remains the cornerstone first-line therapy for type 2 diabetes mellitus, yet its dominant therapeutic mechanism has remained controversial for decades. While traditional models emphasized hepatic gluconeogenesis...
Introduction Post-translational modifications are fundamental regulators of gene expression, chromatin organization and cellular behavior. Dopaminylation, a recently identified modification involving covalent attachment of dopamine to glutamine residues on...
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