Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction The SPINK1 gene encodes the pancreatic secretory trypsin inhibitor, a key protective molecule that prevents premature trypsin activation within the pancreas. Dysfunction of this pathway is central...
Introduction Gallbladder polyps are commonly detected incidentally, with a prevalence of up to 7% in adults. The vast majority are benign, while only a small fraction represent adenomas...
Introduction Intraductal papillary mucinous neoplasm presents a common yet challenging clinical dilemma—whether to operate or observe. The core issue is diagnostic uncertainty, as current imaging and clinical tools...
Introduction Pancreatic ductal adenocarcinoma is a highly aggressive malignancy frequently involving adjacent vascular structures such as the superior mesenteric vein (SMV). Advances in surgical techniques now allow venous...
Introduction Metabolic dysfunction-associated steatotic liver disease is now recognized as a multisystem metabolic disorder affecting not only the liver but also cardiovascular, renal, and endocrine systems. Parallel to...
Introduction With the rapid rise of obesity and type 2 diabetes, incretin-based therapies such as Tirzepatide have transformed metabolic care. These agents offer substantial benefits in weight reduction...
Introduction Autoimmune pancreatitis (AIP) is a unique IgG4-related inflammatory disease with generally favourable outcomes following glucocorticoid therapy. However, beyond pancreatic inflammation, extension into the peripancreatic vasculature can occur,...
Introduction: Metastatic pancreatic cancer continues to carry a dismal prognosis, with limited effective options after failure of first-line gemcitabine-based therapy. Liposomal irinotecan (nal-IRI) combined with 5-fluorouracil/leucovorin (5-FU/LV) is...
Introduction Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer and carries a poor prognosis even after curative surgery. Recurrence rates exceed 50%, particularly in patients...
Introduction Cholangiocarcinoma (CCA) is the second most common primary liver cancer and is associated with poor prognosis due to late diagnosis and aggressive tumour biology. Increasing evidence links...
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