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Trending Topics in Gastroenterology

Explore current gastroenterology questions, clinical answers, and emerging research by topic.

31

Rectal Cancer Surgery Rapidly Reshapes the Gut Microbiome : BJS Open | Jun 2026

Introduction: The gut microbiome plays a fundamental role in maintaining intestinal homeostasis through its effects on metabolism, immune regulation, and resistance to pathogenic colonization. Increasing evidence suggests that...

32

Early-Onset Appendiceal Cancer: Better Outcomes but Different Biology: Journal of Gastrointestinal Cancer | June 2026

Early-onset appendiceal cancer, defined as diagnosis before age 50, accounts for nearly one-third of appendiceal malignancies. This NCDB analysis included more than 27,000 patients with appendiceal adenocarcinoma or...

33

Onlay Mesh Preferred in Ventral Hernia Repair : JAMA Surg | May 2026

Introduction: Mesh reinforcement is the standard of care for primary ventral hernia repair, yet the optimal anatomical position for mesh placement remains controversial. Common techniques include onlay, preperitoneal,...

34

Perioperative Immune Modulation Shapes Surgical Recovery : J Cardiothorac Vasc Anesth | May 2026

Introduction Surgery induces a complex inflammatory and immunologic response involving cytokine activation, neuroendocrine stress signaling and tissue repair pathways. While controlled inflammation is necessary for healing, excessive perioperative...

35

Surgical Necrosectomy Retains a Key Role in WON : Ann Surg | May 2026

Introduction Walled-Off Pancreatic Necrosis remains one of the most challenging complications of severe pancreatitis. Over the last decade, minimally invasive and endoscopic step-up approaches have increasingly replaced open...

36

Transanal Irrigation Improves LARS Outcomes : BJS | May 2026

Introduction Low Anterior Resection Syndrome is a major long-term complication following sphincter-preserving rectal cancer surgery and is characterized by fecal urgency, incontinence, clustering, fragmentation and impaired quality of...

37

Prophylactic Negative-Pressure Wound Therapy Reduces Surgical Site Infection After Major Abdominal Surgery : BJS Open | May 2026

Introduction Surgical Site Infection remains one of the most common complications after major abdominal and thoracic surgery, contributing substantially to postoperative morbidity, prolonged hospitalization, reintervention and healthcare expenditure....

38

Liver Margin Positivity Emerges as a Major Determinant of R1 Resection in Perihilar Cholangiocarcinoma : Ann Surg | May 2026

Introduction Perihilar Cholangiocarcinoma remains one of the most technically challenging hepatobiliary malignancies to treat surgically. Achieving an R0 resection is critical because microscopic residual disease strongly influences recurrence...

39

Anastomotic Leak Drives Major Clinical and Economic Burden After Left-Sided Colorectal Surgery : BJS Open | June 2026

Introduction Anastomotic Leak remains one of the most feared complications following Colorectal Surgery. Beyond its immediate morbidity and mortality implications, anastomotic leak substantially disrupts recovery pathways, prolongs hospitalization...

40

Nationwide Prehabilitation Reduces Complications After CRC Surgery : JAMA Surg | May 2026

Introduction Colorectal Cancer surgery remains associated with substantial postoperative morbidity despite advances in minimally invasive techniques and enhanced recovery pathways. Increasing attention has focused on prehabilitation strategies aimed...

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