Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction Total neoadjuvant therapy (TNT) has become a major advance in locally advanced rectal cancer, helping improve systemic control, increase tumor response, and expand the possibility of organ...
Why this review matters Obesity is no longer viewed only as a metabolic disorder; it is now a major cancer-promoting state. This review explains how excess adiposity drives...
Introduction Colorectal cancer (CRC) screening strategies vary worldwide, with fecal immunochemical testing (FIT) widely used in population programs and colonoscopy dominating screening in the United States. The COLONPREV...
Introduction Advanced gastroesophageal cancers (gastric, GEJ, oesophagal adenocarcinoma, and ESCC) have entered a biomarker-led era. This ASCO update reframes first-line choices around four core actionable domains—PD-L1, HER2, dMMR/MSI-H,...
Introduction Locally advanced rectal cancer (LARC; stage II–III) has traditionally been treated with neoadjuvant chemoradiotherapy (CRT) and total mesorectal excision (TME). While effective for local control, this pathway...
The SCREESCO randomised controlled trial provides rare population-level evidence comparing primary colonoscopy, low-threshold faecal immunochemical testing (FIT), and usual care in colorectal cancer (CRC) screening. Over 278,000 Swedish...
This multicentre phase II Japanese trial evaluated a chemotherapy-only neoadjuvant approach—FOLFOXIRI plus bevacizumab without radiotherapy—for MRI-defined high-risk locally advanced rectal cancer (LARC). Thirty-one patients with at least one...
As neoadjuvant therapy expands across tumor types, pathologic response after surgery is increasingly used as a predictor of long-term survival and as a key clinical trial endpoint. However,...
Introduction Physical exercise has long been associated with better cancer outcomes and improved response to immune checkpoint inhibitors (ICIs). Separately, the gut microbiome is now known to influence...
Introduction Early-onset colorectal cancer (EOCRC), defined as CRC diagnosed before the age of 50, is rising globally and has become a leading cause of cancer-related death in young...
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