Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: Resistance to anti-EGFR therapy has traditionally been considered irreversible in metastatic colorectal cancer (mCRC). However, emerging evidence suggests that resistance is dynamic and can be monitored using...
Introduction: Immune checkpoint inhibitors combined with chemotherapy have become the standard first-line treatment for advanced HER2-negative gastric and gastroesophageal junction cancers. This meta-analysis evaluated whether treatment benefits differ...
Introduction: The treatment of advanced gastric cancer is rapidly evolving from conventional chemotherapy to biomarker-driven precision medicine. Claudin 18.2 (CLDN18.2), a tight junction protein selectively expressed in gastric...
Introduction: Cholangiocarcinoma is an aggressive biliary tract malignancy with limited treatment options and poor long-term outcomes. The discovery of fibroblast growth factor receptor 2 (FGFR2) rearrangements in a...
Pancreatic stereotactic body radiotherapy (SBRT) requires highly precise treatment because the pancreas lies immediately adjacent to radiosensitive organs such as the stomach and duodenum. Most centers instruct patients...
Somatostatin receptor (SSTR) imaging with ⁶⁸Ga-DOTATATE PET is a cornerstone for well-differentiated neuroendocrine tumours, but its role in poorly differentiated neuroendocrine carcinoma (NEC) has remained uncertain. Previous retrospective...
Pancreatic stereotactic body radiotherapy (SBRT) requires highly precise treatment because the pancreas lies immediately adjacent to radiosensitive organs such as the stomach and duodenum. Most centres instruct patients...
Introduction: Locoregionally recurrent rectal cancer (LRRC) remains one of the most challenging scenarios in colorectal oncology. Recurrence within the pelvis is often associated with significant morbidity, impaired quality...
Introduction: Despite advances in systemic therapy, metastatic and recurrent pancreatic cancer remains associated with poor survival. Following progression on first-line gemcitabine-based chemotherapy, treatment options have historically been limited....
Introduction: Concerns regarding increasing cancer incidence among adults younger than 50 years have gained global attention over the past decade. Reports from several countries have suggested a rise...
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