Introduction: Acute-on-chronic liver failure (ACLF) is characterized by overwhelming systemic inflammation and immune dysregulation, leading to high short-term mortality. This study used advanced single-cell and spatial transcriptomic technologies to define the immune landscape of ACLF and identify new therapeutic targets for resolving liver inflammation.
Introduction:
Acute-on-chronic liver failure (ACLF) is characterized by overwhelming systemic inflammation and immune dysregulation, leading to high short-term mortality. This study used advanced single-cell and spatial transcriptomic technologies to define the immune landscape of ACLF and identify new therapeutic targets for resolving liver inflammation.
Why was this study needed?
Results:
Clinical Impact:
This study provides one of the most comprehensive immune maps of ACLF to date and identifies Annexin A1 as a promising pro-resolving therapeutic target. Rather than broadly suppressing immunity, therapies enhancing inflammation resolution may represent a new treatment paradigm for ACLF.
Bottom Line:
ACLF is driven by profound immune dysregulation rather than inflammation alone. Enhancing the ANXA1–FPR1 pathway promotes resolution of liver inflammation and represents a promising next-generation therapeutic strategy for acute-on-chronic liver failure.
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Introduction: Acute-on-chronic liver failure (ACLF) is characterized by overwhelming systemic inflammation and immune dysregulation, leading to high short-term mortality. This study used advanced single-cell and spatial transcriptomic technologies to define the immune landscape of ACLF...
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