The CORE model, developed by researchers at Karolinska Institutet, predicts the 10-year risk of developing severe liver diseases, such as cirrhosis and liver cancer, using a simple blood test. It combines three routinely measured liver enzyme levels (AST, ALT, GGT) with age and sex.
The CORE model, developed by researchers at Karolinska Institutet, predicts the 10-year risk of developing severe liver diseases, such as cirrhosis and liver cancer, using a simple blood test. It combines three routinely measured liver enzyme levels (AST, ALT, GGT) with age and sex. The model demonstrated 88% predictive accuracy, outperforming the widely used FIB-4 method, and is particularly suited for primary care settings. Validated in cohorts from Finland and the UK, it is accessible via a web-based calculator (www.core-model.com). Further testing among high-risk groups is needed, and efforts are underway to integrate it into electronic medical record systems for streamlined clinical use.
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Introduction: Acute-on-chronic liver failure (ACLF) is characterized by overwhelming systemic inflammation and immune dysregulation, leading to high short-term mortality. This study used advanced single-cell and spatial transcriptomic technologies to define the immune landscape of ACLF...
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