Introduction: Mirikizumab, a selective IL-23p19 inhibitor, has demonstrated efficacy in phase III clinical trials for moderate-to-severe ulcerative colitis (UC). This multicenter Italian real-world study evaluated its effectiveness and safety in routine clinical practice, including patients previously exposed to multiple biologic therapies.
Introduction:
Mirikizumab, a selective IL-23p19 inhibitor, has demonstrated efficacy in phase III clinical trials for moderate-to-severe ulcerative colitis (UC). This multicenter Italian real-world study evaluated its effectiveness and safety in routine clinical practice, including patients previously exposed to multiple biologic therapies.
Why was this study needed?
Randomised trials often exclude complex patients with prior biologic failures and multiple comorbidities. Real-world data are essential to determine whether mirikizumab performs similarly in everyday clinical practice.
What did the study show?
Clinical Impact:
These findings reinforce mirikizumab as an effective treatment option for moderate-to-severe UC in routine clinical practice, including patients with previous biologic exposure. The favorable safety profile and consistent clinical response support its use across a broad spectrum of patients.
Take-Home Message:
This real-world multicenter study confirms that mirikizumab is an effective and well-tolerated therapy for ulcerative colitis, achieving meaningful steroid-free remission even in biologic-experienced patients. These results support its growing role as an important IL-23–targeted treatment in everyday clinical practice.
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Introduction: Mirikizumab, a selective IL-23p19 inhibitor, has demonstrated efficacy in phase III clinical trials for moderate-to-severe ulcerative colitis (UC). This multicenter Italian real-world study evaluated its effectiveness and safety in routine clinical practice, including patients...
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