Introduction: Antibiotic exposure is the best-established risk factor for Clostridioides difficile infection (CDI). However, the contribution of many commonly prescribed non-antibiotic medications has remained uncertain.
Introduction:
Antibiotic exposure is the best-established risk factor for Clostridioides difficile infection (CDI). However, the contribution of many commonly prescribed non-antibiotic medications has remained uncertain. This large Swedish population-based study evaluated the association between a wide range of medications and the risk of developing CDI.
Why was this study needed?
As polypharmacy becomes increasingly common, especially among older adults, understanding which medications influence CDI risk is essential for preventing avoidable infections and promoting safer prescribing practices.
What did the study show?
Clinical Impact:
Beyond antibiotic stewardship, clinicians should regularly review non-antibiotic medications that may increase CDI risk, particularly in elderly patients, hospitalized individuals, and those receiving multiple medications. Judicious use of PPIs, corticosteroids, and antidiarrheals may help reduce preventable CDI.
Take-Home Message:
CDI risk extends beyond antibiotics. Careful medication review—including PPIs, corticosteroids, antidiarrheals, and other commonly prescribed drugs—should become an integral part of CDI prevention, especially in patients with multiple risk factors or polypharmacy.
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