Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: Ursodeoxycholic acid (UDCA) remains the first-line treatment for primary biliary cholangitis (PBC), yet a substantial proportion of patients fail to achieve complete biochemical response. Persistent elevation of...
Introduction: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that frequently progresses to liver failure, recurrent bacterial cholangitis, and the need for liver transplantation. Because the...
Introduction Chronic Hepatitis B remains a leading global cause of cirrhosis and Hepatocellular Carcinoma despite the availability of potent antiviral therapy. However, management strategies are rapidly evolving from...
Introduction Acute Liver Failure caused by Hepatitis A remains an important cause of mortality in young adults in developing countries. Although Therapeutic Plasma Exchange has shown benefit in...
Bepirovirsen is an antisense oligonucleotide that targets HBV transcripts, aiming to reduce viral proteins and achieve a functional cure rather than lifelong viral suppression. In two large Phase...
Introduction Metabolic dysfunction–associated steatohepatitis (MASH) has become a major global liver disease burden and a central focus of therapeutic development. Despite intense pharmaceutical activity and numerous late-phase clinical...
Introduction Hepatitis B virus (HBV) infection remains a major global health threat, with an estimated 254 million people living with chronic infection and more than 1.1 million deaths...
Risk stratification in primary biliary cholangitis (PBC) traditionally relies on biochemical response to ursodeoxycholic acid, but liver stiffness measurement (LSM) is increasingly used to assess fibrosis and portal...
Introduction Hepatocellular carcinoma (HCC) commonly arises from chronic liver injury due to hepatitis B virus (HBV), alcohol use, metabolic dysfunction, or combinations of these factors. While each risk...
Indications of EUS-Guided Liver Biopsy EUS-guided liver biopsy (EUS-LB) is increasingly utilized as a minimally invasive technique for obtaining liver tissue samples. Common indications for EUS-LB include: Evaluation...
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