The global incidence of colonoscopy-related adverse events (AEs) was analysed through a comprehensive meta-analysis of 82 population-based studies involving 38. 5 million colonoscopies across 24 countries.
The global incidence of colonoscopy-related adverse events (AEs) was analysed through a comprehensive meta-analysis of 82 population-based studies involving 38.5 million colonoscopies across 24 countries. The study categorised AEs into gastrointestinal and nongastrointestinal events. Gastrointestinal AEs included perforation (5.15 per 10,000 procedures), bleeding (18.39 per 10,000), and splenic injury (0.61 per 10,000). Nongastrointestinal AEs included cardiovascular events (52.11 per 10,000), respiratory events (4.26 per 10,000), and deaths (0.18 per 10,000). Despite the low overall risk, the findings emphasise the need for ongoing efforts to improve the safety of colonoscopy procedures. Subgroup analyses revealed some variability based on factors such as study design, region, and sample size. Most studies included in the analysis demonstrated a low to moderate risk of bias.
Introduction: Endoscopic metabolic therapies have emerged as less invasive alternatives to bariatric surgery for patients with obesity and poorly controlled type 2 diabetes mellitus (T2DM). The EndoBarrier duodenal-jejunal bypass liner (DJBL) is an endoscopically placed...
Introduction: Endoscopic ultrasound (EUS)-guided transmural drainage is the standard minimally invasive treatment for symptomatic necrotizing pancreatitis. However, the optimal timing of direct endoscopic necrosectomy (DEN) following drainage remains uncertain. While the conventional step-up approach reserves...
Introduction: Bevacizumab is widely used in metastatic colorectal cancer (mCRC) because of its survival benefits but is associated with impaired wound healing, gastrointestinal perforation, and bleeding. These concerns often lead clinicians to delay endoscopic procedures...
Introduction: Endoscopic submucosal dissection (ESD) enables en bloc resection of large colorectal neoplasms with excellent oncological outcomes. However, concerns about perforation have limited its widespread adoption. This large prospective multicenter study evaluated the incidence, risk...
Introduction: Obesity has become one of the greatest global health challenges. New incretin-based therapies—including semaglutide, tirzepatide, resmetirom, and SGLT2 inhibitors such as empagliflozin—have transformed the treatment of obesity, diabetes, and MASLD. However, many patients discontinue...
Introduction: Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is the standard technique for diagnosing solid pancreatic lesions. Traditionally, biopsy specimens are processed for cytology, often requiring on-site cytopathology support. This multicenter prospective study evaluated whether directly placing...
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