Introduction: Liver transplantation is limited by a shortage of suitable donor organs. Current viability assessment relies on needle biopsy, which samples only a small portion of the liver and may miss important regional pathology.
Introduction:
Liver transplantation is limited by a shortage of suitable donor organs. Current viability assessment relies on needle biopsy, which samples only a small portion of the liver and may miss important regional pathology. This study evaluated polarization-sensitive optical coherence tomography (PS-OCT), a noninvasive imaging technique, for comprehensive whole-organ donor liver assessment.
Why was this study needed?
Results:
Clinical Impact:
This study represents a major advance in donor liver evaluation. PS-OCT combines high-resolution imaging with artificial intelligence to assess the entire liver rather than a small biopsy sample, potentially improving transplant decision-making and expanding the usable donor pool.
Bottom Line:
PS-OCT may redefine donor liver viability assessment. By providing accurate, noninvasive, whole-organ evaluation that correlates with graft function and transplant outcomes, it has the potential to reduce organ discard and safely expand liver transplantation.
Introduction: Bacterial infections remain a major cause of morbidity after liver transplantation despite advances in perioperative care. Synbiotics, combining probiotics and prebiotics, have been proposed to reduce postoperative infections by restoring gut microbiota and strengthening...
Introduction: Perioperative bleeding remains a major challenge during orthotopic liver transplantation (OLT), largely due to hyperfibrinolysis and coagulation abnormalities. Although tranexamic acid (TXA) effectively reduces bleeding in several surgical settings, its routine prophylactic use during...
Introduction: Bleeding remains a major challenge during liver transplantation despite advances in surgical techniques, anesthesia, and perioperative care. Antifibrinolytic agents have long been used to reduce intraoperative blood loss and transfusion requirements. However, evolving transplant...
Introduction: The demand for liver transplantation continues to exceed the availability of deceased donor organs, resulting in prolonged waiting times and preventable waitlist mortality. This perspective discusses how living donor liver transplantation (LDLT) can complement...
Introduction: Pediatric liver transplantation has achieved excellent survival rates, shifting the focus from graft survival alone to optimising long-term health, growth, neurodevelopment, and quality of life. This updated guideline provides evidence-based recommendations for comprehensive care...
Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by severe pruritus and elevated bile acids, carrying risks for both maternal well-being and fetal outcomes. Management can be particularly challenging in patients...
We are pioneers in clinical intelligence, dedicated to helping gastroenterologists harness the power of artificial intelligence to drive precision, efficiency, and patient growth.