Liver Transplantation
Overview
Advancing outcomes through surgical excellence.
Improving Medication Adherence After Liver Transplantation: Liver Transplantation | August 2026
Introduction: Long-term adherence to immunosuppression is essential after liver transplantation, yet medication nonadherence remains an important preventable cause of poor graft and patient outcomes. This systematic review and meta-analysis evaluated medication simplification, pharmacist-led care, behavioral...
Prioritizing Low-Risk HCC Patients for Liver Transplant May Worsen Waitlist Outcomes for Higher-Risk Candidates: Liver Transplantation | July 2026
Introduction: Liver transplantation (LT) offers the greatest survival benefit for patients with hepatocellular carcinoma (HCC) at high risk of disease progression while awaiting transplant. However, current allocation policies provide similar transplant priority regardless of an...
Behavioural Alcohol Use Disorder Therapy During Liver Transplant Evaluation: Liver Transplantation | July 2026
Introduction: Liver transplantation is increasingly being offered to carefully selected patients with alcohol-associated liver disease (ALD) who have less than six months of sobriety. This multicenter study evaluated whether behavioural alcohol use disorder therapy (bAUDT)...
Bilateral Duct-to-Duct Reconstruction in Dual Left Graft LDLT: Liver Transplantation | July 2026
Introduction: In dual left graft living donor liver transplantation (LDLT), reconstruction of the bile ducts is technically demanding because rotation of the right-sided graft alters the anatomical relationship between the bile duct and portal vein....
Liver Transplantation After Chemotherapy and SIRT for Unresectable Intrahepatic Cholangiocarcinoma: Journal of Hepatology | July 2026
Introduction: Liver transplantation (LT) has traditionally not been recommended for unresectable intrahepatic cholangiocarcinoma (iCCA) because of historically poor outcomes. This study evaluated whether neoadjuvant chemotherapy combined with selective internal radiation therapy (SIRT) could identify a...
Predicting Liver Failure After Locoregional Therapy: Liver Transplantation | May 2026
Introduction: Locoregional therapy (LRT) is a cornerstone treatment for early- and intermediate-stage hepatocellular carcinoma (HCC), but post-procedure liver dysfunction remains a major concern. This study evaluated which pre-treatment factors best predict liver failure following LRT....
Synbiotics After Liver Transplant Show No Clinical Benefit: Liver Transplant | July 2026
Introduction: Bacterial infections remain a major cause of morbidity after liver transplantation despite advances in perioperative care. Synbiotics, combining probiotics and prebiotics, have been proposed to reduce postoperative infections by restoring gut microbiota and strengthening...
Tranexamic Acid in Liver Transplantation: Liver Transplant | June 2026
Introduction: Perioperative bleeding remains a major challenge during orthotopic liver transplantation (OLT), largely due to hyperfibrinolysis and coagulation abnormalities. Although tranexamic acid (TXA) effectively reduces bleeding in several surgical settings, its routine prophylactic use during...
Whole-Organ Donor Liver Assessment Using PS-OCT: Science Translational Medicine | July 2026
Introduction: Liver transplantation is limited by a shortage of suitable donor organs. Current viability assessment relies on needle biopsy, which samples only a small portion of the liver and may miss important regional pathology. This...
Personalizing Antifibrinolytic Use in Liver Transplantation : Liver Transpl | Jul 2026
Introduction: Bleeding remains a major challenge during liver transplantation despite advances in surgical techniques, anesthesia, and perioperative care. Antifibrinolytic agents have long been used to reduce intraoperative blood loss and transfusion requirements. However, evolving transplant...
Integrating LDLT into Modern Liver Transplant Programs: Liver Transplantation | June 2026
Introduction: The demand for liver transplantation continues to exceed the availability of deceased donor organs, resulting in prolonged waiting times and preventable waitlist mortality. This perspective discusses how living donor liver transplantation (LDLT) can complement...
Post-Transplant Management in Pediatric LT: Liver Transplantation | June 2026
Introduction: Pediatric liver transplantation has achieved excellent survival rates, shifting the focus from graft survival alone to optimising long-term health, growth, neurodevelopment, and quality of life. This updated guideline provides evidence-based recommendations for comprehensive care...
IBAT Inhibitor Relieves Refractory ICP After Liver Transplant : Liver Transpl | Jun 2026
Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by severe pruritus and elevated bile acids, carrying risks for both maternal well-being and fetal outcomes. Management can be particularly challenging in patients...
Post-Transplant Infections Drive Early Readmissions : Liver Transpl | Apr 2026
Introduction: Hospital readmission within 30 days of liver transplantation is a common and costly event that reflects early postoperative morbidity and is increasingly used as a quality metric in transplant care. Early readmissions place substantial...
Frailty at 1 Year Predicts Long-Term Mortality After Liver Transplant : Liver Transpl | June 2026
Introduction: Frailty is increasingly recognized as a key determinant of outcomes in patients with advanced liver disease and has become an important component of liver transplant evaluation. Although many patients experience functional recovery after liver...
GLP-1RAs Aid Weight Control After Liver Transplant : Liver Transpl | June 2026
Introduction: Weight gain and metabolic dysfunction are increasingly recognized as major challenges after liver transplantation. Obesity, diabetes, dyslipidemia, and metabolic dysfunction–associated steatotic liver disease can adversely affect graft health, increase cardiovascular risk, and compromise long-term...
Redefining Early Allograft Dysfunction in LDLT : Liver Transpl | Jun 2026
Introduction: Early allograft dysfunction (EAD) remains one of the most important early indicators of graft performance after liver transplantation. Traditionally, EAD has been defined using biochemical parameters developed largely from deceased donor liver transplantation populations....
Bucharest Consensus: Ethical Standards for Controlled DCDD: Transplant International | June 2026
Controlled donation after circulatory determination of death is becoming an increasingly important pathway to expand deceased organ donation worldwide. This ESOT Bucharest international consensus provides practical, ethical, and operational standards for adult controlled DCDD programs....
HOPE Reduces Early Liver Graft Dysfunction : JAMA Surg | May 2026
Introduction: Introduction: Liver transplantation increasingly relies on extended-criteria donor (ECD) and donation-after-circulatory-death (DCD) grafts to address organ shortages. However, these grafts are more susceptible to ischemia-reperfusion injury, which contributes to early allograft dysfunction (EAD), prolonged...
Preemptive Anti-Craving Therapy May Reduce Post-Transplant Alcohol Relapse : Liver Transpl | May 2026
Introduction Alcohol-Associated Liver Disease has become one of the leading indications for Liver Transplantation worldwide. Although transplantation provides excellent survival benefit, post-transplant alcohol relapse remains a major concern because it can contribute to graft injury,...
ACLF Definitions: JCTH | May 2026
Acute-on-chronic liver failure (ACLF) is a severe syndrome characterized by acute decompensation, organ failure, and high short-term mortality in patients with cirrhosis. However, ACLF lacks a universally accepted definition. Multiple frameworks exist globally, leading to...
Ferroptosis Blockade Improves Liver and Lung Graft Function : Cell | May 2026
Introduction Ischemia–reperfusion injury (IRI) remains a major barrier in organ transplantation and contributes significantly to graft dysfunction, early allograft injury and organ discard. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation,...
Living-Donor Liver Transplantation Improves Survival in Unresectable Colorectal Liver Metastases : Liver Transpl | May 2026
Introduction Colorectal liver metastases remain a major cause of cancer-related mortality, and curative treatment is traditionally limited to patients eligible for hepatic resection. However, many patients present with technically unresectable liver-only disease despite favorable tumor...
ABO-Incompatible Liver Transplantation Shows Comparable Outcomes in Children | Liver Transplantation
Introduction Liver transplantation is the definitive treatment for children with end-stage liver disease, yet waitlist mortality remains a major challenge, particularly in infants and critically ill children with limited donor availability. ABO-incompatible (ABO-I) liver transplantation...
Cardiovascular Disease Remains a Major Threat After Kidney and Liver Transplantation Heart | 2026
Introduction Kidney and liver transplantation substantially improve survival and quality of life in patients with end-stage organ disease. However, cardiovascular disease (CVD) remains a leading cause of long-term morbidity and premature mortality after transplantation. Despite...
Deceased Donor Liver Transplantation Increases Risk of Biliary Cast Syndrome Liver Transplantation | April 2026
Introduction Biliary cast syndrome (BCS) is an uncommon but clinically significant biliary complication after liver transplantation, characterized by the formation of obstructive biliary debris within the graft biliary tree. It has traditionally been associated with...
Post-Transplant Liver Assessment: Liver Transplantation | April 2026
Introduction Liver transplantation has dramatically improved survival in patients with end-stage liver disease and hepatocellular carcinoma. However, long-term outcomes are often compromised by complications such as graft rejection, recurrent disease, or de novo liver pathology...
Hepatic Hypoxia in Donation After Circulatory Death (DCD): Liver Transplantation | February 2026
Introduction Donation after circulatory death (DCD) has emerged as an important strategy to expand the donor pool in liver transplantation. However, compared to brain-dead donors, DCD grafts are more vulnerable to hypoxic injury due to...
Modified Cavo-Portal Hemi-Transposition in Adult LDLT: Annals of HPB Surgery | February 2026
Introduction Extensive porto-mesenteric thrombosis has traditionally been considered one of the most difficult situations in liver transplantation because adequate portal inflow is essential for graft regeneration and long-term function. In living donor liver transplantation, this...
Selective Splenectomy Guided by Graft-to-Spleen Volume Ratio in LDLT: Liver Transplantation | April 2026
Introduction Early allograft dysfunction (EAD) remains a major challenge after living donor liver transplantation (LDLT), often driven by portal hyperperfusion and small-for-size graft physiology. Splenectomy has been used to modulate portal flow, but its routine...
Neuroprotection in ALF: Journal of Hepatology | March 2026
Introduction Neuroprotection remains a central challenge in the management of acute liver failure, where cerebral oedema and intracranial hypertension are major drivers of mortality. Traditionally, invasive intracranial pressure monitoring has been used to guide management,...
Post LT Immunosuppressive Strategies for PSC: Journal of Hepatology | March 2026
Introduction Primary sclerosing cholangitis is a unique indication for liver transplantation because long-term outcomes are influenced not only by graft survival, but also by the risks of acute cellular rejection, recurrent PSC, and complications related...
Transplant Timing in Perihilar Cholangiocarcinoma: Ann of Surgery, Feb. 2026
This large single-centre analysis evaluated whether earlier liver transplantation improves survival in patients with perihilar cholangiocarcinoma (pCCA) treated with standardised neoadjuvant therapy and transplant protocol. The key question: Does transplanting within 6 months of protocol...
Managing Multiple Bile Ducts in LDLT- Liver Transplant Feb.26
Multiple bile ducts (MBDs) in living donor liver transplantation (LDLT) remain a major technical challenge, particularly in right lobe grafts. This large retrospective study analysed 1,780 microsurgical biliary reconstructions over 16 years to determine optimal...
The Liver Transplant Comorbidity Index- Hepatology Feb.26
Frailty is a powerful predictor of outcomes after liver transplantation, but it cannot be used alone to determine transplant candidacy because many frail patients still achieve acceptable survival. This multicenter prospective study introduces the Liver...
Gut–liver–muscle axis -Front. Med. 2026
The Gut–Liver–Muscle Axis: Overview and Key Insights The "gut-liver-muscle axis" is an emerging concept that highlights the interconnected relationship between gut microbiota, liver metabolism, and skeletal muscle health. This axis provides a framework to understand...
AASLD–AST Practice Guideline on Adult Liver Transplantation
The AASLD–AST (American Association for the Study of Liver Diseases and the American Society of Transplantation) Practice Guideline on Adult Liver Transplantation provides a comprehensive framework for the management of adult liver transplant recipients. This...
Donor Microbiota Signatures Predict Short-Term Liver Transplant Outcomes
Yes, donor microbiota signatures, specifically those derived from the intrahepatic microbiome, can predict short-term liver transplant outcomes. The study you referenced highlights several key findings that establish the predictive value of donor microbiota signatures in...
AASLD–AST Guideline on Non-Graft Complications After Adult Liver Transplantation
The AASLD–AST (American Association for the Study of Liver Diseases–American Society of Transplantation) guideline focuses on the diagnosis, prevention, and management of non-graft-related complications that significantly impact the long-term health of adult liver transplant recipients....
AASLD–AST Guideline on Adult Liver Transplant Candidate Evaluation
The AASLD–AST Guideline on Adult Liver Transplant Candidate Evaluation provides a comprehensive, evidence-based framework for assessing patients who may benefit from liver transplantation. This updated guideline, developed by a multidisciplinary expert panel, reflects advancements in...
Pediatric Immunosuppression
Pediatric immunosuppression is a critical aspect of care for children undergoing liver transplantation, aimed at preventing graft rejection while minimizing adverse effects. Recent studies, including the ChILiSFree study and other research, have provided valuable insights...
Benefit and harm of waiting time in liver transplantation for HCC
The waiting time in liver transplantation (LT) for hepatocellular carcinoma (HCC) has both benefits and potential harms, depending on its duration and the management strategies applied during this period. Below is a detailed breakdown of...
Targeted enteral feeding for malnutrition in liver transplant candidates
Targeted enteral feeding, specifically nasogastric feeding (NGF), has been studied as a potential strategy to address malnutrition in liver transplant candidates. Malnutrition is a critical concern in this patient population because it significantly impacts surgical...
Colorectal cancer liver metastasis (CRLM) and Liver Transplantation
Liver transplantation (LT) is emerging as a viable treatment option for colorectal cancer liver metastases (CRLM), offering promising outcomes for select patients. A large multicenter study analyzing 82 patients from 2006 to 2020 revealed favorable...
Sedoanalgesia during TIPS placemen
Sedoanalgesia during transjugular intrahepatic portosystemic shunt (TIPS) placement refers to the combined use of sedation and analgesia to ensure patient comfort, pain relief, and reduced anxiety during this invasive procedure. TIPS is a complex interventional...
Novel biomarkers, liver regeneration following plasma exchange in ALF
Liver regeneration is a critical biological process where the liver repairs and restores its tissue following injury or damage. In the context of acute liver failure (ALF), liver regeneration is especially significant, as it determines...
Therapeutic plasma exchange in acute liver failure
Therapeutic plasma exchange (TPE) is a medical procedure used to remove and replace a patient's plasma, which can contain harmful substances or toxins contributing to disease pathology. In the context of acute liver failure (ALF),...
LTSI consensus guidelines for the management of acute liver injury caused by yellow phosphorus
The Liver Transplant Society of India (LTSI) consensus guidelines for the management of acute liver injury (ALI) caused by yellow phosphorus (YP) poisoning emphasize the critical need for early recognition, hospitalization, supportive care, and timely...
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