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Trending Topics in Gastroenterology

Explore current gastroenterology questions, clinical answers, and emerging research by topic.

11

Robotic vs Laparoscopic Cholecystectomy: JAMA Surgery | July 2026

Introduction: Robotic cholecystectomy continues to expand worldwide, but its value compared with conventional laparoscopy remains debated. This large study evaluated whether the robotic platform offers meaningful clinical or...

12

MEK Inhibitor–Immunotherapy in Cholangiocarcinoma: Hepatology | July 2026

Introduction: Advanced cholangiocarcinoma (CCA) remains difficult to treat, with limited benefit from current chemotherapy and immunotherapy combinations. This study investigated whether combining a MEK inhibitor (MEKi), anti-PD-L1 therapy,...

13

Ivonescimab Plus Gemcitabine–Cisplatin in Biliary Tract Cancer (BTC): Journal of Hepatology | July 2026

Introduction: Advanced biliary tract cancer (BTC) carries a poor prognosis, with limited improvements in survival despite the addition of immune checkpoint inhibitors to standard gemcitabine–cisplatin chemotherapy. This phase...

14

GLP-1 Receptor Agonists and Gallbladder Disease: UEG Journal | June 2026

Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a cornerstone in the management of type 2 diabetes because of their excellent glycemic, cardiovascular, and weight-loss benefits. However,...

15

Remnant Duct Dilatation Rarely Signals IPMN Recurrence : Ann Surg | Jun 2026

Introduction: Patients undergoing pancreatoduodenectomy for non invasive intraductal papillary mucinous neoplasm (IPMN) require long-term surveillance because of the risk of disease recurrence in the pancreatic remnant. New pancreatic...

16

Post-Pancreatectomy Chyle Leak: Annals of Surgery | June 2026

This study evaluated 1,063 patients undergoing pancreatic surgery; 11% developed conventionally defined chyle leak. Most clinically relevant cases were grade B, while no grade C leaks were reported....

17

Immediate Necrosectomy Accelerates Recovery in Walled-Off Necrosis : Gastroenterology | Jul 2026

Introduction: Endoscopic ultrasound (EUS)-guided drainage has become the preferred minimally invasive treatment for symptomatic necrotizing pancreatitis. However, the optimal timing of direct endoscopic necrosectomy (DEN) following drainage remains...

18

Fatty Pancreas: A Hidden Burden in T2DM : Diabetes Res Clin Pract | June 2026

Introduction: Fatty pancreas disease (FPD), also known as intrapancreatic fat deposition, has emerged as an important metabolic condition closely linked to obesity, insulin resistance, and type 2 diabetes...

19

Selective Use of Biliary Drainage Supported in pCCA : BJS | Jun 2026

Introduction: Preoperative biliary drainage (PBD) is frequently used in patients with perihilar cholangiocarcinoma (pCCA) to relieve biliary obstruction before surgery. The proposed benefits include improved liver function, reduced...

20

Pancreatic Plasticity in Development and Disease : Nat Rev Gastroenterol Hepatol | May 2026

Introduction The pancreas represents one of the most dynamic models of cellular plasticity in human biology, where developmental fate decisions, tissue maintenance and regenerative responses are orchestrated through...

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