Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: KRAS mutations drive the vast majority of pancreatic cancers, but KRAS G12C represents only about 1–2% of cases. This small molecular subgroup is increasingly actionable. The FDA...
Introduction: Systemic inflammation plays a major role in pancreatic ductal adenocarcinoma (PDAC), contributing to tumor progression, cachexia, and treatment resistance. The Systemic Inflammation Response Index (SIRI) combines neutrophil,...
Introduction: Vitamin B6 participates in cholesterol metabolism, oxidative stress regulation, and inflammatory pathways that may influence gallstone formation. This population-based analysis examined whether dietary vitamin B6 intake is...
Introduction: Fatty pancreas is increasingly recognized as an ectopic fat depot with metabolic consequences, but its clinical significance has been difficult to define because previous studies used inconsistent...
Introduction: Dual immune checkpoint blockade with nivolumab plus ipilimumab has shown activity across several malignancies, but its role in advanced biliary tract cancer remains uncertain. The Phase II...
Introduction: Pancreatic ductal adenocarcinoma (PDAC) frequently develops resistance to chemotherapy through metabolic adaptations that enhance tumor survival. New research from the University of Oklahoma is investigating whether pancreatic...
Introduction: Distinguishing benign from malignant biliary strictures remains one of the greatest challenges in pancreatobiliary endoscopy. Although ERCP brush cytology and biopsy have excellent specificity, their sensitivity is...
Introduction: Pancreatic enzyme replacement therapy (PERT) is the standard treatment for exocrine pancreatic insufficiency (EPI) but is currently derived exclusively from porcine pancreatic extracts, requiring multiple capsules and...
Introduction: Accurate tumour segmentation is fundamental for precision oncology, enabling objective assessment of tumour burden, treatment response, and radiomics analysis. This study developed and validated an anatomically constrained...
Introduction: The widespread detection of intraductal papillary mucinous neoplasms (IPMNs) has substantially increased surveillance programs, although only a small proportion progress to pancreatic cancer. This study evaluated the...
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