Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
What Did the Study Find? This study combined a large PSC-UC surveillance cohort with a novel experimental model to investigate why PSC-UC carries disproportionate colorectal neoplasia risk. Compared...
What Did the Study Find? study evaluated serum REG3α, a Paneth-cell protein, across two established Crohn’s disease cohorts and a unique prediagnostic cohort. Among 394 patients, higher REG3α...
Introduction: Progression from MASH to fibrosis and hepatocellular carcinoma (HCC) involves lipotoxicity, oxidative stress, inflammation, and hepatocyte death. This review positions ferroptosis—iron-dependent, lipid-peroxidation-driven cell death—as a potential upstream...
Introduction: Sarcopenia—the age-related loss of skeletal muscle mass, strength, and function—contributes to frailty, falls, fractures, disability, and mortality. Despite its growing burden, there are currently no approved pharmacological...
Introduction: Microbiome abnormalities have been identified before Crohn’s disease (CD) develops, but association does not prove biological relevance. This study asked a powerful question: can stool collected from...
Introduction: Leptin has powerful metabolic effects, but leptin resistance in obesity limits its therapeutic potential. This study shows that FGF21 can restore peripheral leptin sensitivity, creating a synergistic...
Introduction: Neurodegenerative diseases often evolve silently for years before neurological symptoms appear. By the time Parkinson’s disease, dementia or amyotrophic lateral sclerosis becomes clinically apparent, substantial and potentially...
Neutrophil extracellular traps (NETs) are DNA-rich webs released by neutrophils to capture pathogens, but excessive NET activity can also promote inflammation. This study identifies an unexpected role for...
Introduction: Obesity is more than excess adiposity—it produces biological changes that overlap substantially with the hallmarks of aging. This review examines how obesity may accelerate biological aging and...
Introduction: Oxidative stress and abnormal hepatic iron metabolism are increasingly recognized as interconnected drivers of progression from steatosis to MASH and fibrosis. This review proposes an “oxidative stress–iron...
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