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Trending Topics in Gastroenterology

Explore current gastroenterology questions, clinical answers, and emerging research by topic.

01

For Refractory Faecal Incontinence, Biofeedback Matches Injection at Lower Cost: CGH | October 2026

What Did the Study Find? The five-centre FIT trial enrolled adults experiencing at least four faecal-incontinence episodes over two weeks despite medical and behavioural therapy. Two hundred nonresponders—176...

02

FIT-Positive but No Colorectal Cancer: Frontline Gastroenterology | October 2026

What Did the Study Find? This real-world study followed 1,056 symptomatic FIT-positive patients without colorectal cancer (CRC) to evaluate alternative diagnoses and their relationship with faecal haemoglobin concentrations....

03

DENEB Blood Test Detects Both Colorectal Cancer and Advanced Adenomas—But Is Not Screening-Ready: The Lancet Gastroenterology & Hepatology | October 2026

What Did the Study Find? DENEB developed a blood assay combining 19 cell-free and 20 exosomal microRNAs, measured by RT-qPCR and interpreted using locked machine-learning models. Biomarkers were...

04

FMT as First-Line Therapy for Checkpoint-Inhibitor Colitis: Cell Reports Medicine | October 2026

What Did the Study Find? This early-phase study evaluated first-line fecal microbiota transplantation (FMT) in 13 patients with cancer who developed grade ≥2 immune checkpoint inhibitor–mediated diarrhea and...

05

“Nonadvanced” Adenomas Are Not One Risk Category: Gastroenterology | October 2026

What Did the Study Find? Investigators studied 16,870 adults aged 50–75 years who underwent at least two colonoscopies between 2004 and 2023. During a median 5.3 years, five-year...

06

New US Guidance Defines How to Diagnose, Clear and Survey Serrated Polyposis Syndrome: Gastroenterology | 30 September 2026

What Did the Guideline Find? The Task Force recommends diagnosing serrated polyposis syndrome using the 2019 WHO cumulative-lifetime criteria, making accurate documentation of every serrated lesion’s number, size...

07

Malignant Oesophagal Stricture With Airway Involvement: Check the Airway Before You Stent: FG | October 2026

What Did the Study Find? This tertiary-centre study evaluated 26 patients with malignant oesophagal strictures undergoing same-session upper GI endoscopy and bronchoscopy because of suspected oesophageal–airway involvement. 81%...

08

IBS Beyond the Gut–Brain Axis: Is Triglyceride Biology Part of the Story?: Gut | September 2026

What Did the Study Find? The largest genetic study of IBS to date analyzed ~2.8 million individuals across 22 international biobanks, integrating different IBS definitions and subtypes. Researchers...

09

Appendiceal Adenocarcinoma Is Not Colon Cancer: JAMA Surgery | September 2026

What Did the Study Find? This large study evaluated 439 patients with stage I–III appendiceal adenocarcinoma, with external validation and median follow-up exceeding 5 years. Relapse after curative...

10

STARS Phase III: Once-Weekly Apraglutide Reduces Parenteral-Support Dependence in Short-Bowel Syndrome: CGH | September 2026 | Phase III STARS Trial

Introduction: Patients with short-bowel syndrome with intestinal failure (SBS-IF) may require long-term parenteral support, creating substantial treatment burden and catheter-related risks. STARS evaluated apraglutide, a once-weekly GLP-2 analogue,...

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