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Trending Topics in Gastroenterology

Explore current gastroenterology questions, clinical answers, and emerging research by topic.

01

Nicotine Pouches: JAMA | July 2026

Introduction: Nicotine pouches are an increasingly popular smokeless oral nicotine product marketed as an alternative to cigarettes and other tobacco products. This review summarises their composition, health effects,...

02

Dopamine Beyond Reward. JAMA| May 2026

This review redefines dopamine (DA) signaling beyond its classical role in reward processing, positioning dopaminergic circuits as central regulators of feeding behavior, metabolic sensing, and energy homeostasis. The...

03

Gut–Heart Axis: Gut | May 2026

Introduction Atherosclerosis has traditionally been viewed as a lipid-driven disease. However, emerging evidence highlights a critical role of chronic inflammation and immune activation, with the gut microbiota now...

04

Bleeding Risk with Apixaban vs. Rivaroxaban: NEJM March 2026

Clinical Summary In this randomized international trial (COBRRA), investigators compared the bleeding risk of apixaban vs. rivaroxaban in patients with acute venous thromboembolism (VTE), including pulmonary embolism and...

05

ACG 2025

The American College of Gastroenterology (ACG) 2025 meeting is a prominent annual event where groundbreaking research, clinical studies, and advancements in gastroenterology are presented. At the ACG 2025...

06

Alcohol Use Disorder (AUD) with Alcohol-Related Liver Disease (ArLD) - Pharmacology

Alcohol Use Disorder (AUD) and Alcohol-Related Liver Disease (ArLD) often coexist, presenting a complex clinical challenge that requires careful consideration of pharmacological treatment. Below is a detailed explanation...

07

The role of copper dysregulation in Wilson disease

Copper dysregulation plays a central role in the pathogenesis of Wilson disease (WD). The disease arises from the body’s inability to regulate copper levels, leading to its accumulation...

08

Molecular basis of alcohol abstinence and relapse in alcohol-associated liver disease

The molecular basis of alcohol abstinence and relapse in alcohol-associated liver disease (ALD) involves complex interactions between the gut-liver-brain axis, immune system, neurotransmitters, and signaling pathways. Here is...

09

Differential Diagnosis of Intestinal Tuberculosis (ITB) vs Crohn’s Disease (CD)

Differentiating Intestinal Tuberculosis (ITB) from Crohn’s Disease (CD) is one of the most challenging diagnostic dilemmas in clinical practice, particularly in tuberculosis (TB)-endemic regions. Both disorders share overlapping...

10

Albumin-corrected anion gap (ACAG) and mortality in GI bleeding

The albumin-corrected anion gap (ACAG) is a calculated laboratory parameter that adjusts the traditional anion gap (a measure of the difference between measured cations and anions in the...

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