Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: HCC treatment has traditionally been closely linked to staging systems such as BCLC. However, modern multidisciplinary care increasingly includes TARE, external-beam radiotherapy, systemic therapy, and combined approaches...
Introduction: Resection and liver transplantation remain the main curative-intent treatments for hepatocellular carcinoma (HCC), but recurrence after surgery is common and many patients present outside conventional surgical or...
Introduction: Immunotherapy-based combinations have transformed first-line treatment of unresectable HCC, but the optimal strategy after progression remains uncertain because no phase III trial has yet defined a standard...
Introduction: TACE remains a standard treatment for embolisation-eligible HCC, but recurrence and progression are common. Because TACE can enhance tumor antigen release and immune activation, combining it with...
Introduction: Systemic therapy has traditionally been the mainstay for HCC with macrovascular invasion. However, increasingly effective immunotherapy-based regimens can produce substantial tumor regression, raising an important question: should...
Introduction: Atezolizumab plus bevacizumab (Atezo–Bev) transformed first-line treatment of unresectable hepatocellular carcinoma (HCC), but long-term follow-up from the pivotal IMbrave150 trial was limited. The prospective Italian ARTE study...
Introduction: Current HCC surveillance relies on ultrasound with AFP every 6 months, but ultrasound has limited sensitivity in patients with obesity or steatosis and real-world adherence remains suboptimal....
Introduction: Cirrhosis, portal hypertension, and hepatocellular carcinoma (HCC) are closely interconnected, yet clinical guidelines frequently approach portal hypertension and HCC as separate entities. This review proposes an integrated,...
Introduction: Regular surveillance is essential for the early detection of hepatocellular carcinoma (HCC) in high-risk patients, increasing the likelihood of curative treatment. However, real-world adherence to surveillance remains...
Introduction: Early detection of hepatocellular carcinoma (HCC) is critical for improving access to curative therapies, yet current surveillance with ultrasound and alpha-fetoprotein (AFP) has suboptimal sensitivity, particularly in...
We are pioneers in clinical intelligence, dedicated to helping gastroenterologists harness the power of artificial intelligence to drive precision, efficiency, and patient growth.