Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
What’s New? The FDA has approved Bexlutry (lutetium Lu-177 dotatate) for adults with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut, midgut and hindgut NETs. Bexlutry becomes a...
Introduction: The role of radiation therapy (RT) in pancreatic cancer has remained controversial, particularly as systemic therapy has improved. The updated ASTRO guideline incorporates newer trials and advances...
Introduction: The neutropenic diet traditionally restricts fresh fruits, vegetables, and other foods considered potential sources of infection in immunocompromised patients. Despite widespread historical use, whether these restrictions actually...
What’s New? The FDA has cleared a first-in-human trial of an experimental dual-targeted CAR T-cell therapy developed for advanced colorectal cancer, with clinical testing expected to begin in...
What Did the Study Find? MATTERHORN randomized 948 patients with resectable gastric or gastro-oesophageal junction adenocarcinoma to perioperative durvalumab + FLOT or placebo + FLOT. Durvalumab significantly improved...
What Did the Study Find? This meta-analysis of 45 studies, including >650,000 patients, compared adenocarcinomas of the distal esophagus, GEJ, and stomach diagnosed before age 50 with later-onset...
Introduction: Adagrasib + cetuximab received accelerated FDA approval for previously treated KRAS G12C-mutated metastatic colorectal cancer (mCRC). Following failure of the confirmatory KRYSTAL-10 Phase III trial to demonstrate...
Introduction: Bevacizumab plus chemotherapy remains an established first-line option for metastatic colorectal cancer (mCRC). ANCHOR tested whether the oral multitargeted TKI anlotinib + CapeOX could provide a convenient...
Introduction: Colonoscopy can detect and remove precancerous lesions, but randomised evidence demonstrating its population-level impact remains limited. NordICC provides long-term data on whether invitation to a single screening...
What Did the Study Find? This 19-year real-world study evaluated 692 patients with locally advanced, resectable gastroesophageal adenocarcinoma, including 394 who received neoadjuvant systemic therapy. Most patients showed...
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