Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: The combination of chemotherapy and immune checkpoint inhibitors (ICIs) is now the standard first-line treatment for advanced oesophagal squamous cell carcinoma (ESCC). Emerging evidence from several cancers...
Introduction: Approximately 3–6% of metastatic colorectal cancers (mCRC) harbor HER2 amplification, particularly in RAS/BRAF wild-type tumors. HER2-targeted therapies such as trastuzumab-based combinations and trastuzumab deruxtecan have significantly improved...
Introduction: Neoadjuvant therapy (NAT) has become an integral component of treatment for patients with operable pancreatic ductal adenocarcinoma (PDAC). However, assessing treatment response remains challenging because biochemical markers...
Introduction: Antibody–drug conjugates (ADCs) have transformed cancer treatment by combining the precision of monoclonal antibodies with the potency of cytotoxic drugs, enabling targeted delivery of chemotherapy directly to...
Introduction: Advanced biliary tract cancer (BTC) and pancreatic cancer (PC) are highly aggressive malignancies with limited treatment options and poor survival after progression on standard therapy. Although HER2...
Introduction: Chemotherapy-induced thrombocytopenia (CIT) is a common dose-limiting toxicity in patients with gastrointestinal (GI) cancers, often leading to treatment delays, dose reductions, or premature discontinuation of chemotherapy. Persistent...
Introduction: Immune checkpoint inhibitors combined with platinum-based chemotherapy have become the standard first-line treatment for HER2-negative unresectable advanced or recurrent gastric and gastroesophageal junction (GEJ) cancers. However, many...
Introduction: Despite curative surgery for stage I–III colorectal cancer (CRC), 10–30% of patients develop recurrence, most commonly within the first two years. Conventional postoperative surveillance using CT scans...
Introduction: Acute kidney injury (AKI) is a frequent and serious complication following cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), particularly with cisplatin-based regimens. This study evaluated whether...
Introduction: Claudin 18.2 (CLDN18.2) has emerged as a key therapeutic target in gastric and gastroesophageal junction (GEJ) adenocarcinoma. The Phase III CLARITY-Gastric01 trial evaluated sonesitatug vedotin, an anti-CLDN18.2...
We are pioneers in clinical intelligence, dedicated to helping gastroenterologists harness the power of artificial intelligence to drive precision, efficiency, and patient growth.