Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
What Did the Study Find? A single-centre trial randomized 297 people with MASLD to minimal intervention comprising usual care and written advice (102), structured lifestyle coaching (97), or...
What Did the Study Find? Investigators analysed 4,302 individuals with Metabolic dysfunction-associated steatotic liver disease and hypertension in the international VCTE-Prognosis cohort. Participants were followed for a median...
What Did the Study Find? Investigators analysed nearly 200,000 participants from the Nurses’ Health Study, Nurses’ Health Study II and Health Professionals Follow-Up Study. Late-night eating was defined...
What Did the Study Find? This analysis restricted MAESTRO-NASH to 917 patients with biopsy-confirmed F2 or F3 fibrosis, aligning the trial population with the clinical indication for resmetirom....
What Did the Study Find? This 12-centre US trial randomised 67 adults with overweight or obesity and MASLD/MASH to once-weekly zabopegdutide—DD01, a dual GLP-1/glucagon-receptor agonist—or placebo. Seventy-eight per...
MASH pharmacotherapy is now recommended for F2–F3 disease. Adults with non-cirrhotic MASH and significant/advanced fibrosis (F2–F3) should be considered for resmetirom or semaglutide, always alongside lifestyle and cardiometabolic...
What Did the Study Find? This large Global MASLD study evaluated 18,326 patients with biopsy-confirmed MASLD across 41 countries, including 1,224 patients (6.7%) classified as lean by BMI....
What Did the Study Find? The phase III REIMAGINE 5 trial compared once-weekly CagriSema 1.0 mg/1.0 mg with tirzepatide 5 mg in adults with type 2 diabetes inadequately...
What Does This Update Add? With resmetirom and semaglutide now available for non-cirrhotic MASH with significant F2–F3 fibrosis, this international expert panel provides a practical framework for moving...
What Did the Study Find? This prospective study evaluated 186 patients with or at risk for MASLD, using biopsy and/or MRE to identify clinically relevant fibrosis. 38% had...
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