Introduction: Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is the standard technique for diagnosing solid pancreatic lesions. Traditionally, biopsy specimens are processed for cytology, often requiring on-site cytopathology support.
Introduction:
Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is the standard technique for diagnosing solid pancreatic lesions. Traditionally, biopsy specimens are processed for cytology, often requiring on-site cytopathology support. This multicenter prospective study evaluated whether directly placing FNB tissue in formalin for histopathology could provide comparable diagnostic performance.
Why was this study needed?
Results:
Clinical Impact:
This study supports direct formalin submission of EUS-FNB specimens for histopathology as a practical alternative to cytology, particularly in centers without ROSE or cytopathology services. It may simplify specimen processing while maintaining excellent diagnostic performance.
Bottom Line:
Histopathology with MOSE is a reliable alternative to cytology for EUS-FNB of solid pancreatic lesions. It provides comparable diagnostic accuracy with fewer needle passes, making it an attractive approach for routine clinical practice, especially in resource-limited settings.
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