Introduction: Hepatitis B virus (HBV) reactivation remains a potentially serious complication of immunosuppressive and anticancer therapies. While current guidelines classify patients into high-, moderate-, and low-risk categories, this editorial discusses new real-world evidence suggesting that HBV reactivation risk is more dynamic than previously appreciated.
Introduction:
Hepatitis B virus (HBV) reactivation remains a potentially serious complication of immunosuppressive and anticancer therapies. While current guidelines classify patients into high-, moderate-, and low-risk categories, this editorial discusses new real-world evidence suggesting that HBV reactivation risk is more dynamic than previously appreciated.
Key Takeaways:
Clinical Impact:
This editorial reinforces current guideline recommendations while emphasizing that "low risk" should never be interpreted as "no risk." Careful HBV screening, individualized risk assessment, close monitoring, and timely antiviral prophylaxis remain essential for patients receiving immunosuppressive therapy.
Bottom Line:
HBV reactivation risk exists across the entire spectrum of immunosuppressive therapy. Rather than depending solely on static drug-based categories, clinicians should adopt a dynamic, patient-centered approach that accounts for cumulative immunosuppression and individual risk factors.
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