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Fibrosis & MASLD

8
NAFLD Fibrosis ScoreAdvanced fibrosis probability in MASLD/NAFLDBARD ScoreBMI, AST/ALT ratio, diabetes — MASLD fibrosisFatty Liver IndexPredicts hepatic steatosis from routine labsFibrotic NASH Index (FNI)At-risk NASH probability from AST, HbA1c and HDLNAFLD Activity Score (NAS)Histologic activity grade — steatosis, inflammation, ballooningMEFIB IndexMRE + FIB-4 rule for significant fibrosis (≥F2) in MASLDFAST ScoreFibroScan-AST — at-risk NASH from LSM, CAP and ASTSAFE ScoreSteatosis-Associated Fibrosis Estimator for MASLD in primary care

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8
Ranson's CriteriaAcute pancreatitis severity at 48 hoursGlasgow-Imrie CriteriaAcute pancreatitis severity — the PANCREAS criteriaHAPSHarmless acute pancreatitis scoreTokyo Guidelines — CholangitisTG18 diagnosis and severity grade for acute cholangitisTokyo Guidelines — CholecystitisTG18 diagnosis and severity grade for acute cholecystitisBiliary Pain (Rome IV)Rome IV — defining biliary-type pain before interventionFunctional Pancreatic SODRome IV — pancreatic sphincter of Oddi disorderRevised Atlanta ClassificationAcute pancreatitis severity — mild, moderately severe, severe

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Truelove & Witts CriteriaAcute severe ulcerative colitis — admission decisionUCEISUlcerative colitis endoscopic index of severitySCCAISimple clinical colitis activity index — symptoms onlyCDAICrohn's disease activity index — the trial standardSES-CDEndoscopic severity in Crohn's diseasePUCAIPaediatric ulcerative colitis activity indexTravis (Oxford) CriteriaDay 3 colectomy risk in acute severe ulcerative colitisHo IndexDay 3 steroid failure risk in acute severe ulcerative colitisRutgeerts ScorePostoperative Crohn's recurrence at ileocolonoscopy

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4
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Colorectal

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Boston Bowel Prep ScaleColonoscopy preparation adequacy by segmentStool Osmotic GapOsmotic vs secretory diarrhoea from stool electrolytesATLAS Score (C. difficile)Predicted response to therapy in Clostridioides difficile infection

Functional GI

37
Bristol Stool ScaleStool form types 1–7 and colonic transitRome IV Criteria for IBSIrritable bowel syndrome diagnosis and subtypeFunctional ConstipationRome IV — two of six items, IBS excludedOpioid-Induced ConstipationRome IV — constipation tied to opioid therapyFunctional DiarrhoeaRome IV — loose stools without predominant painFunctional Bloating / DistensionRome IV — bloating without other bowel disorder criteriaUnspecified Functional Bowel DisorderRome IV — bowel symptoms fitting no other categoryCentrally Mediated Abdominal Pain (CAPS)Rome IV — continuous pain unrelated to gut eventsNarcotic Bowel SyndromeRome IV — opioid-induced hyperalgesia of the gutFaecal Incontinence (Rome IV)Rome IV — the criteria, and why nobody is askedFunctional Anorectal PainLevator ani, unspecified pain and proctalgia fugaxFunctional Defecation DisordersRome IV — dyssynergia and inadequate propulsionInfant RegurgitationRome IV — the happy spitter, and the alarm features that rule it outInfant ColicRome IV — recurrent unexplained crying in a well infant under 5 monthsInfant DyscheziaRome IV — straining before a soft stool, and why not to intervenePaediatric Functional ConstipationRome IV — two of six over one month, with overflow soiling as a criterionToddler's DiarrhoeaRome IV functional diarrhoea of childhood — painless, thriving childPaediatric Cyclic Vomiting SyndromeRome IV — both age bands, with different criteria for eachPaediatric Rumination SyndromeRome IV — infant and child/adolescent criteriaFunctional Nausea & Vomiting (Children)Rome IV — two separate disorders that can be met togetherAerophagiaRome IV — distension that increases through the dayPaediatric Functional DyspepsiaRome IV — four times a month, with PDS and EPS subtypingPaediatric Irritable Bowel SyndromeRome IV — plus the constipation clause clinicians missAbdominal MigraineRome IV — stereotypical incapacitating episodes weeks apartFunctional Abdominal Pain — NOSRome IV — the residual category, reached after the other threeNonretentive Faecal IncontinenceRome IV — soiling without retention, where laxatives make it worseFunctional DyspepsiaRome IV — with PDS and EPS subtypingRumination SyndromeRome IV — effortless regurgitation without retchingCyclic Vomiting SyndromeRome IV — stereotypical episodic vomitingCannabinoid HyperemesisRome IV — CVS pattern relieved by cannabis cessationChronic Nausea & VomitingRome IV — chronic nausea and vomiting syndromeBelching DisordersRome IV — supragastric vs gastric belchingFunctional HeartburnRome IV — heartburn with normal acid exposureReflux HypersensitivityRome IV — normal acid exposure, positive symptom associationFunctional Chest PainRome IV — non-cardiac, non-reflux chest painGlobusRome IV — painless lump-in-throat sensationFunctional DysphagiaRome IV — dysphagia with normal endoscopy and manometry
  1. Calculators
  2. /
  3. Toddler's Diarrhoea
Functional GI

Toddler's Diarrhoea

Rome IV functional diarrhoea of childhood — painless, thriving child

Four or more a day, and painless. Pain moves this towards a different diagnosis.

Four weeks, not the three months used in adult criteria — the paediatric chapters use shorter windows throughout.

Six months to five years. Outside that window the diagnosis does not apply.

Normal growth is what separates this from malabsorption. The caveat matters — a child who is not being fed enough will not thrive for reasons unrelated to the bowel.

Painless is the key word. A thriving toddler passing frequent unformed stools without pain and without weight loss has a benign condition that needs no work-up.

When to use
Use it for the preschool child, typically between one and four years old, whose parents describe several loose and often startlingly recognisable stools every day, and who is nevertheless growing normally and behaving normally. It is a frequent reason for referral to paediatric gastroenterology and a frequent reason for extensive and unnecessary investigation. Apply it before ordering tests rather than after they return normal, because the criteria are constructed so that a child who meets them does not need the tests in the first place.
Why use it
Because this is a diagnosis that can be made positively rather than by exclusion, and making it positively is what spares the child a work-up. The four criteria between them exclude the conditions that matter: pain and blood point elsewhere, faltering growth points to malabsorption, an onset outside the age window points to something other than a developmental pattern. What remains is a child who is well. The second reason is that the treatment is genuinely effective and genuinely counterintuitive. Families presented with a child passing frequent loose stools reduce fat and increase clear fluids, both of which make it worse, and both of which are reversible in a single consultation once the mechanism is explained.
Formula, evidence and interpretation

About the Rome IV Criteria for Functional Diarrhoea of Childhood (Toddler's Diarrhoea)

Painless is the word that carries this diagnosis. Four criteria must all hold: daily painless recurrent passage of four or more large unformed stools; symptoms lasting more than four weeks; onset between six and sixty months of age; and no failure to thrive provided caloric intake is adequate. A thriving child passing frequent loose stools without pain, without blood and without night-time symptoms has a benign condition that resolves by school age and needs no investigation. The commonest thing keeping it going is not a disease but a diet — excessive fruit juice, sorbitol and a low fat intake, all three of which are usually introduced by families trying to help.

On this page

  • Formula
  • Interpreting the result
  • Inputs
  • What it returns
  • How it is calculated
  • Facts & figures
  • Evidence
  • How it compares
  • Pearls & pitfalls
  • Critical actions
  • Why it exists
  • About the creator
  • Limitations
  • If you are the patient
  • FAQ
  • Related calculators
  • References

Formula

Functional diarrhoea of childhood = ≥ 4 large unformed stools per day, painless and recurrent AND duration > 4 weeks AND onset between 6 and 60 months of age AND no failure to thrive (given adequate caloric intake)
Painless
The discriminating qualifier. Abdominal pain with the stools takes the child towards irritable bowel syndrome, which in Rome IV is a separate paediatric diagnosis with its own criteria.
Large, unformed
Not watery and not small-volume. Stools are typically bulky and may contain recognisable undigested food, which is where the informal name comes from.
Adequate caloric intake
A conditional attached to the growth criterion. It exists because dietary restriction imposed in an attempt to treat the diarrhoea is itself a common cause of poor weight gain in these children.
  • Four weeks, against three months in the adult functional diarrhoea criteria — the paediatric duration rules are consistently shorter.
  • Nocturnal stooling is not part of the criteria but argues strongly against the diagnosis in practice.
  • Undigested food in the stool is characteristic and is not evidence of malabsorption in a thriving child.
  • The condition is expected to resolve by school age without treatment.

Interpreting the result

Meeting criteria should end the diagnostic process rather than begin it. Take a detailed dietary history with actual volumes rather than impressions, because fruit juice intake is routinely underestimated and is the single most productive thing to address — withdrawing it is often curative on its own. Restore dietary fat to an age-appropriate level and say explicitly that fat is therapeutic here, since the instruction otherwise sounds like indifference to the symptom. Check that fibre intake is neither excessive nor negligible. Then give the natural history: this resolves by school age, it does not cause harm in the meantime, and the child's normal growth is the evidence that nothing is being lost. Where criteria are not met, the failing item directs the assessment and each points somewhere specific. Pain with the stools suggests paediatric irritable bowel syndrome. Faltering growth despite adequate intake requires investigation for coeliac disease, cystic fibrosis, giardiasis and other causes of malabsorption. Blood, nocturnal stooling, fever or perianal disease point towards inflammatory bowel disease and are outside functional territory entirely. Onset before six months or after five years falls outside the definition and warrants a fresh assessment rather than an extension of the label.

ScoreBandWhat it meansAction
Criteria metFunctional diarrhoea of childhoodPainless frequent unformed stools in a thriving child aged 6–60 months at onsetDietary review — reduce juice and sorbitol, restore fat; reassure; no investigation required
Criteria not met — pain presentConsider paediatric IBSAbdominal pain accompanying the stoolsAssess against the Rome IV paediatric irritable bowel syndrome criteria
Criteria not met — faltering growthNot functionalPoor weight gain despite adequate caloric intakeInvestigate for coeliac disease, cystic fibrosis, giardiasis and other malabsorptive causes
Criteria not met — outside the age windowOutside the definitionOnset before 6 months or after 60 months of ageReassess rather than applying the label outside its age band

What the Toddler's Diarrhoea needs (4 inputs)

Daily painless, recurrent passage of four or more large, unformed stools
Four or more per day, and painless. Pain accompanying the stools moves the assessment towards irritable bowel syndrome or an inflammatory cause, and it is the single most important qualifier in the criterion.
Symptoms last more than 4 weeks
Four weeks, not the three months used throughout the adult criteria. The paediatric committees shortened every duration rule on the grounds that families and children should not have to wait a quarter of a year for a diagnosis that can be made sooner.
Onset between 6 and 60 months of age
Six months to five years. The window is part of the definition, and diarrhoea beginning outside it is not this condition regardless of how closely the stool pattern matches.
No failure to thrive if caloric intake is adequate
The conditional matters. A child who is not being offered enough calories will not grow, and that failure says nothing about the bowel — the criterion asks whether growth is normal given what is actually being eaten.

What it returns

Criteria met or not met
All four are required.
Which criterion is outstanding
Reported explicitly, because the failing criterion determines the next step — pain, faltering growth and an out-of-window onset each lead somewhere different.

How it is calculated

The mechanism is transit rather than absorption, which is why growth is preserved. Preschool children have a relatively rapid intestinal transit, and where the osmotic load reaching the colon exceeds what it can reclaim, the result is frequent bulky unformed stool without any loss of nutrition. Three dietary factors reliably push the balance in that direction, and all three are common in this age group. Fruit juice supplies fructose and sorbitol, both of which are absorbed slowly and incompletely, and juice intake in toddlers is frequently far above what anyone intends. Sorbitol appears independently in apple and pear juice and in sugar-free products. A low fat intake removes the main physiological brake on transit — fat slows gastric emptying and small bowel transit, and diets restricted in fat move material through faster. The self-perpetuating part is that each of these tends to be introduced in response to the diarrhoea. Parents offer more clear fluid because the child is passing loose stools and they fear dehydration, and they reduce fat because it seems intuitively heavy. Both worsen the problem they were adopted to treat, and both are reversible. Undigested food in the stool follows from the same rapid transit and is not a sign that anything is failing to be absorbed, which is worth stating plainly because it is the finding families find most alarming.

Facts & figures

The dietary drivers, and what to do about each
FactorEffectPractical step
Fruit juice (fructose)Incompletely absorbed; delivers osmotic load to the colonQuantify intake honestly, then reduce substantially — often curative alone
Sorbitol (apple and pear juice, sugar-free products)Poorly absorbed sugar alcohol; osmotic effectIdentify hidden sources and remove them
Low dietary fatRemoves the physiological brake on transitRestore age-appropriate fat; state explicitly that this is treatment
Excessive fluid volume of any kindIncreases the load presented to the colonNormalise total intake rather than pushing fluids for fear of dehydration
Very high fibre intakeAdds bulk and accelerates transit furtherModerate rather than increase

Each of these is commonly introduced in response to the diarrhoea itself, which is why the dietary history is worth taking in detail rather than in outline.

Evidence

Derivation — Rome Foundation, neonate/toddler committee

2016

Consensus criteria from the Rome IV committee on childhood functional gastrointestinal disorders in the neonate and toddler, published in Gastroenterology in 2016.

Consensus-derived. Rome IV retained the condition largely as defined in Rome III, keeping the four-week duration and the 6–60 month onset window.

How it compares

Toddler's Diarrhoea vs Paediatric irritable bowel syndrome

Pain is the divide — functional diarrhoea of childhood is painless by definition, and IBS requires abdominal pain.

The stool pattern alone does not separate these, since a child with diarrhoea-predominant IBS may pass stools that look identical. Rome IV settles it on pain, which paediatric IBS requires and this diagnosis explicitly excludes. Age helps as well: functional diarrhoea of childhood begins between six and sixty months and resolves by school age, while paediatric IBS is a diagnosis of older children and adolescents and requires the child to be able to report the pain reliably. Getting this right changes management substantially, since IBS brings a different set of interventions and a different natural history.

Open the Paediatric irritable bowel syndrome calculator →

Toddler's Diarrhoea vs Coeliac disease

Growth is the discriminator — coeliac disease that presents with chronic diarrhoea in a preschool child almost always disturbs the growth trajectory.

Coeliac disease is the alternative most clinicians reach for, and it is a reasonable one. What distinguishes it here is that classical coeliac presenting at this age with diarrhoea characteristically comes with faltering growth, abdominal distension and irritability, whereas functional diarrhoea of childhood leaves the centiles untouched. Rome IV builds this into the criteria through the growth requirement rather than mandating serology. Where growth is faltering, or where there is any other atypical feature, serology is appropriate; where all four criteria are met in a thriving child, it is not the first step.

Toddler's Diarrhoea vs Giardiasis

The infectious mimic worth remembering, and the one where a stool test is genuinely indicated when the picture does not quite fit.

Giardia lamblia produces chronic loose stools in preschool children, is readily transmitted in nurseries and other group settings, and can persist for months. It differs in that it more often causes abdominal pain, bloating and flatulence, and it frequently does affect weight gain. Where those features are present, or where there is a relevant exposure history and the four criteria are not cleanly satisfied, stool testing is worthwhile. The point of the Rome IV criteria is not that infection never needs excluding but that a painless, thriving child who fits all four items does not need it excluded routinely.

Pearls & pitfalls

  • Painless is the criterion that does the most work. Pain with the stools moves the child towards paediatric IBS and out of this diagnosis.
  • Ask for fruit juice intake in millilitres per day, not in impressions. It is consistently underestimated and is the commonest single driver.
  • Restoring dietary fat is treatment, not indifference — say so, or the advice will be heard as dismissal.
  • Undigested food in the stool is expected here and is not evidence of malabsorption in a thriving child.
  • Four weeks, not three months. Applying the adult duration rule delays the diagnosis unnecessarily.
  • Nocturnal stooling is not in the criteria but should prompt a rethink — functional diarrhoea does not typically wake children.
  • Normal growth is the safety net. Check it against measured intake rather than assuming inadequate weight gain implicates the bowel.
  • Sorbitol hides in apple and pear juice and in sugar-free products, and is missed when only 'juice' is asked about.
  • The condition resolves by school age. Giving that horizon explicitly reduces repeat presentations more than any dietary advice.
  • Resist stool cultures and coeliac serology in a thriving, painless, well child who meets all four criteria — the criteria exist precisely to make that testing unnecessary.

Critical actions

  • Plot growth on a centile chart and review the trajectory rather than a single point.
  • Take a quantified dietary history covering juice, squash, sorbitol-containing products, total fluid volume, fat and fibre.
  • Confirm the stools are painless and that there is no blood, mucus, fever or nocturnal stooling.
  • Establish the age at onset and check it falls between six and sixty months.
  • Reduce fruit juice and other sorbitol sources substantially.
  • Restore age-appropriate dietary fat and explain why.
  • Avoid investigation in a child meeting all four criteria with normal growth.
  • Give the natural history explicitly, including resolution by school age.
  • Arrange review to confirm growth is maintained and symptoms are improving with dietary change.

Why this score exists

The conditional buried in the growth criterion — 'if caloric intake is adequate' — is the most considered phrase in this definition. Normal growth is what makes the diagnosis safe, so it would have been simpler to require it outright. The committee did not, because by the time these children are referred a substantial number have been placed on restricted diets in an attempt to control the diarrhoea, and some of them are no longer growing well as a result. Requiring normal growth without qualification would have pushed exactly those children out of the functional category and into a malabsorption work-up, when the cause of both the poor growth and the persisting diarrhoea was the dietary management. The clause asks the clinician to judge growth against what the child is actually being offered, which is a harder question than reading a centile chart and a more useful one.

About the creator

  • Marc A. Benninga

    First author, Rome IV neonate/toddler functional gastrointestinal disorders committee

    Chaired the committee that produced the Rome IV criteria for this age band.

  • Paul E. Hyman

    Co-author; paediatric gastroenterology

    Contributed to the neonate and toddler chapter of Rome IV.

  • Samuel Nurko

    Co-author; paediatric neurogastroenterology and motility

    Contributed to the neonate and toddler chapter of Rome IV.

Limitations

  • Consensus criteria with no external validation, and the four-stool threshold is a convention rather than a measured cut-off.
  • Dependent on caregiver report of stool frequency and consistency, both of which are estimated rather than recorded.
  • 'Large' and 'unformed' are not defined, and no stool scale is specified.
  • The 6–60 month onset window is arbitrary at both ends and excludes children whose presentation is otherwise identical.
  • No severity grading, so a child with four stools a day and one with ten receive the same label.
  • The criteria do not name the dietary factors that drive the condition, despite diet being the mainstay of treatment.
  • Nocturnal stooling — a useful red flag in practice — appears nowhere in the definition.
  • There is no guidance on how long to persist with dietary modification before reconsidering the diagnosis.

If you are the patient

Toddler's diarrhoea means a young child who passes several loose, bulky stools every day — often with bits of recognisable food in them — but who is otherwise perfectly well, growing normally, and not in any pain. It is common, it is not a disease, and it does not mean your child is failing to absorb their food. The reason food appears undigested is simply that it is moving through quickly, not that anything is being lost, and the proof of that is your child's normal growth. It settles on its own, usually by the time a child starts school. The most useful thing you can do is look at what your child drinks. Fruit juice is the commonest cause by a long way, because the sugars in it are absorbed slowly and pull water into the bowel. Apple and pear juice are the worst offenders, and sugar-free drinks and sweets contain a similar substance called sorbitol. Cutting these right down often fixes the problem on its own. The second thing is fat, and this one surprises people: children with this pattern need normal amounts of fat in their diet, because fat slows things down. If you have been giving low-fat foods to try to help, that is very likely making it worse, and going back to full-fat milk and normal cooking is part of the treatment. Do go back to your doctor if your child has tummy pain with the stools, blood in the stools, is opening their bowels at night, has a fever, or stops gaining weight — none of those fit this diagnosis and they need looking at properly.

Frequently asked questions

What are the Rome IV criteria for functional diarrhoea of childhood?#

Daily painless recurrent passage of four or more large unformed stools; symptoms lasting more than four weeks; onset between six and sixty months of age; and no failure to thrive provided caloric intake is adequate. All four are required.

Is toddler's diarrhoea the same as functional diarrhoea of childhood?#

Yes. Toddler's diarrhoea is the informal name, and chronic nonspecific diarrhoea of childhood is the older formal one. Rome IV calls it functional diarrhoea and places it in the neonate and toddler chapter with the criteria above.

Why does fruit juice make it worse?#

Fructose and sorbitol are both absorbed slowly and incompletely in young children, so a high juice intake delivers an osmotic load to the colon that exceeds what it can reclaim. The result is frequent bulky unformed stool. Apple and pear juice contain sorbitol as well as fructose and are the worst offenders. Intake is routinely underestimated, so it is worth asking for volumes rather than impressions.

Should dietary fat be reduced?#

No — the opposite. Fat slows gastric emptying and small bowel transit, so it acts as a brake on the rapid transit driving the symptom. Low-fat diets adopted in an attempt to help are a common perpetuating factor, and restoring age-appropriate fat intake is part of the treatment rather than a concession.

Does undigested food in the stool mean malabsorption?#

Not in a child who is growing normally. Recognisable food fragments follow from rapid transit, not from failure to absorb nutrients, and normal growth is the evidence that absorption is intact. It is the finding families find most alarming, so it is worth addressing directly rather than waiting to be asked.

What tests are needed?#

In a child who meets all four criteria, is painless and is growing normally, none are required — the criteria are constructed so that testing is unnecessary. Testing becomes appropriate when a criterion fails: faltering growth despite adequate intake, pain, blood, fever or nocturnal stooling all take the child out of this diagnosis and warrant investigation.

When does it resolve?#

By school age in the great majority, and often sooner once dietary drivers are addressed. Giving families that horizon explicitly is worth doing, because uncertainty about duration is what brings most of them back.

How does it differ from paediatric IBS?#

Pain. Functional diarrhoea of childhood is painless by definition, whereas Rome IV requires abdominal pain for paediatric irritable bowel syndrome. Age helps too — this condition begins between six and sixty months and resolves by school age, while paediatric IBS is a diagnosis of older children and adolescents.

Related calculators

  • Paediatric Irritable Bowel Syndrome — Rome IV — plus the constipation clause clinicians miss
  • Infant Dyschezia — Rome IV — straining before a soft stool, and why not to intervene
  • Paediatric Functional Constipation — Rome IV — two of six over one month, with overflow soiling as a criterion
  • Functional Abdominal Pain — NOS — Rome IV — the residual category, reached after the other three
  • Infant Colic — Rome IV — recurrent unexplained crying in a well infant under 5 months

References

Original / primary reference

  1. Benninga MA, Nurko S, Faure C, Hyman PE, St James Roberts I, Schechter NL. Childhood Functional Gastrointestinal Disorders: Neonate/Toddler. Gastroenterology. 2016;150(6):1443-1455 (Rome IV).

Dietary contributors

  1. Heyman MB, Abrams SA; AAP Section on Gastroenterology, Hepatology, and Nutrition and Committee on Nutrition. Fruit Juice in Infants, Children, and Adolescents: Current Recommendations. Pediatrics. 2017;139(6):e20170967.

Differential diagnosis

  1. Husby S, Koletzko S, Korponay-Szabo I, Kurppa K, Mearin ML, Ribes-Koninckx C, et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr. 2020;70(1):141-156.
  2. Lacy BE, Mearin F, Chang L, Chey WD, Lembo AJ, Simren M, Spiller R. Bowel Disorders. Gastroenterology. 2016;150(6):1393-1407 (Rome IV — the adult functional diarrhoea criteria this disorder is distinct from).

Last updated August 1, 2026. Clinical knowledge base written and curated by GastroAGI Team from primary medical literature.

Written from primary literature and not yet independently clinically reviewed.

For use by qualified healthcare professionals. This calculator supports clinical judgement and does not replace it.