Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
This longitudinal single-cell multiomics study provides a detailed immune roadmap of HBV-related acute-on-chronic liver failure (HBV-ACLF), a syndrome marked by profound immune dysregulation and high short-term mortality. Using...
Alcohol-associated hepatitis (AH) remains a high-mortality condition with limited effective therapies. A central driver of disease progression is excessive hepatic inflammation, particularly massive neutrophil infiltration, triggered by cytokine...
Metabolic dysfunction–associated steatohepatitis (MASH) is rapidly becoming a leading driver of hepatocellular carcinoma (HCC). This comprehensive review highlights endoplasmic reticulum (ER) stress and the unfolded protein response (UPR)...
Metabolic dysfunction–associated steatohepatitis (MASH) is driven by oxidative stress, hepatocyte injury, inflammation, and fibrosis. Activation of the c-Jun N-terminal kinase (JNK) pathway has long been associated with MASH,...
Hepatocellular carcinoma (HCC) displays marked histologic heterogeneity that reflects distinct biological behaviors and treatment responses. Among recognized variants, macrotrabecular–massive HCC (MT-HCC) represents a particularly aggressive subtype characterized by...
Acute-on-chronic liver failure (ACLF) and acute liver failure (ALF) are life-threatening conditions marked by severe hepatic dysfunction combined with overwhelming systemic inflammation. Mortality remains extremely high because no...
Introduction Metabolically–dysfunction–associated steatohepatitis (MASH) is increasingly recognised as a multiorgan disease, with pathogenic signalling extending beyond the liver. Rohm et al. propose an intriguing extrahepatic mechanism: adipose tissue...
Introduction Peutz–Jeghers syndrome (PJS) is a hereditary cancer-predisposition condition caused by germline mutations in LKB1 (STK11). While patients are known to have an increased risk of gastrointestinal cancers,...
What Are Envbiotics? Envbiotics is a term that encapsulates the idea of regulating and optimising gut microbiota indirectly by focusing on the environmental conditions of the gut rather...
It seems you're asking about the concept of serum metabolomic signatures and their summarized results as detailed in the study mentioned in the context. While the specific reference...
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