Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: Bile acids are increasingly recognised as metabolic signalling molecules rather than simply mediators of digestion. This experimental study investigated hyodeoxycholic acid (HDCA) and identified two complementary pathways...
Introduction: Older livers are particularly vulnerable to hepatic ischaemia-reperfusion injury (HIRI) during liver surgery and transplantation, but the underlying mechanisms remain poorly understood. Using single-cell and spatial transcriptomics...
Introduction: Colorectal cancer (CRC) cells require large amounts of iron to sustain rapid growth, DNA synthesis, and mitochondrial metabolism. Paradoxically, excessive intracellular iron is normally toxic because it...
Introduction: Obesity is a major risk factor for at least 13 obesity-associated cancers (OACs), and its global prevalence continues to rise. With the increasing use of GLP-1 receptor...
Introduction: Dendritic cells (DCs) are the key orchestrators of antitumor immunity, responsible for activating cytotoxic T lymphocytes (CTLs) that eliminate cancer cells. While conventional dendritic cell subsets (cDC1...
Introduction: Frailty is a major geriatric syndrome associated with falls, disability, hospitalisation, and reduced quality of life. Although aerobic exercise is widely recommended, the optimal type and dose...
Introduction: Regulatory T cells (Tregs) are essential for maintaining immune tolerance and preventing autoimmune disease. However, within the tumour microenvironment, these same cells suppress antitumor immune responses, allowing...
Introduction: Disorders of gut–brain interaction (DGBI), including irritable bowel syndrome (IBS) and functional dyspepsia (FD), are increasingly recognised as disorders of impaired intestinal barrier function rather than purely...
Introduction: Pancreatic ductal adenocarcinoma (PDAC) develops through complex cellular heterogeneity driven by oncogenic KRAS and chronic inflammation. This study identifies LY6D as a marker of a persistent stem-like,...
Introduction: Aging is increasingly recognized as a process influenced not only by human genetics but also by the microbiome. This review introduces the concept of microbiome age—a computational...
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