Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
ALP + bilirubin remain the core biochemical treatment targets Both ALP and total bilirubin at 12 months consistently predict clinically important outcomes in PBC, including decompensation, transplantation and...
What Does the Review Clarify? This major review provides a practical framework for understanding and investigating occult hepatitis B virus infection (OBI). OBI means replication-competent HBV DNA despite...
Introduction: PBC management is moving beyond simply starting UDCA and assessing response after one year. The new Austrian consensus emphasizes earlier biochemical assessment, more ambitious treatment targets, second-line...
Introduction: PSC is strongly associated with IBD, but screening is usually prompted by abnormal liver biochemistry. The Copenhagen IBD inception cohort examined how often systematic MRCP at IBD...
Introduction: Bulevirtide has transformed treatment of chronic hepatitis D (HDV), but the optimal treatment duration remains uncertain. Final MYR301 data address a crucial practical question: can treatment be...
Introduction: Risk stratification in primary sclerosing cholangitis (PSC) remains challenging because conventional biochemical markers do not reliably predict disease progression. The international FICUS cohort evaluated whether VCTE-based liver...
Topic: Evolving standards of care in primary biliary cholangitis (PBC), with increasing emphasis on ALP normalisation, liver stiffness, second-line PPAR agonists, pruritus, and fatigue. Key Takeaways The treatment...
Introduction: Immune checkpoint inhibitors (ICIs) can cause immune-mediated liver injury, ranging from hepatocellular hepatitis to cholestatic or mixed patterns. Although liver biopsy may clarify the diagnosis and severity,...
Introduction: Primary biliary cholangitis (PBC) is a progressive cholestatic liver disease in which early diagnosis and treatment can prevent progression to cirrhosis. However, many patients remain asymptomatic and...
Introduction: Pruritus is one of the most troublesome symptoms experienced by patients with primary sclerosing cholangitis (PSC), yet its natural history has been poorly understood. As disease-modifying therapies...
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