Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: Chronic visceral pain is one of the most difficult symptoms to treat in diarrhea-predominant IBS (IBS-D). This translational study identified medial prefrontal cortex (mPFC) hyperexcitability as a...
Introduction: Hereditary adenomatous polyposis syndromes are systemic cancer-predisposition disorders involving not only the colorectum but also the stomach, duodenum and other organs. The updated ACG guideline emphasises earlier...
Introduction: Up to one-third of patients with IBD report abdominal pain, altered bowel habits or bloating despite treatment, and approximately one-quarter remain symptomatic even in endoscopic or histologic...
Introduction: CRC screening reduces incidence and mortality, yet participation remains suboptimal. This network meta-analysis of 76 randomized trials compared strategies for improving screening uptake. Why was this study...
Introduction: Vitamin D has long attracted interest as a potential adjunctive treatment in colorectal cancer. Preclinical studies demonstrate antiproliferative, pro-differentiation, anti-inflammatory and immunomodulatory effects, while observational studies have...
Introduction: Rifaximin can improve symptoms in diarrhoea-predominant irritable bowel syndrome (IBS-D), but relapse after treatment remains common. Because rifaximin alters the intestinal microbial environment, post-treatment microbiome modulation may...
Introduction: Recurrent Clostridioides difficile infection (CDI) remains a major clinical challenge, with recurrence occurring in up to one-third of patients after initial treatment. Although both vancomycin taper-and-pulse (VAN-TP)...
Introduction: Increasing evidence suggests that Parkinson's disease (PD) may originate in the gut, with pathological α-synuclein spreading to the brain through the vagus nerve. This preclinical study investigated...
Introduction: Although aspirin has long been investigated as adjuvant therapy for colorectal cancer (CRC), the overall ASCOLT trial showed no improvement in disease-free survival (DFS). This translational analysis...
Introduction: Anal squamous cell carcinoma is an increasingly common but largely preventable cancer. Most cases arise from persistent high-risk human papillomavirus (HPV) infection, progressing through high-grade squamous intraepithelial...
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