Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: Statins are routinely prescribed in metabolic dysfunction-associated steatotic liver disease (MASLD) to reduce cardiovascular risk, but emerging evidence suggests their benefits may extend directly to the liver....
Introduction: Steatotic liver disease (SLD) is increasingly recognized not as a collection of separate disorders but as a dynamic spectrum driven by interacting metabolic and alcohol-related factors. Obesity,...
Introduction: Patients with MASH and advanced fibrosis remain at substantial risk of cirrhosis and liver-related complications. Because MASH involves multiple metabolic and fibrogenic pathways, combination therapy is attractive....
Introduction: The gut–liver axis plays a central role in the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). While previous studies have focused on changes in...
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) involves complex disturbances in hepatic lipid metabolism, oxidative stress, inflammation, and mitochondrial function. NADPH:cytochrome P450 oxidoreductase (CPR), encoded by POR, is...
Introduction: Eating behaviour is governed by complex interactions between the gastrointestinal tract and the brain that generate hunger, satiation, and satiety. This review examines how gut-derived mechanical and...
Researchers at Johns Hopkins have validated an AI-powered DELFI liquid biopsy that accurately detected hepatocellular carcinoma (HCC) in geographically and biologically distinct high-risk populations. Key findings: ✅ Successfully...
Introduction: Reliable noninvasive biomarkers are essential to replace liver biopsy for diagnosing metabolic dysfunction-associated steatohepatitis (MASH) and staging fibrosis. The prospective multicenter LITMUS Imaging Study evaluated the diagnostic...
Introduction: Fibrosis is the principal determinant of long-term outcomes in metabolic dysfunction–associated steatotic liver disease (MASLD). This large international Global-MASLD study evaluated clinical predictors of advanced fibrosis and...
Introduction: Obesity is increasingly recognized as a chronic, adiposity-based disease rather than a condition defined solely by body mass index (BMI). Recent guidelines from major international organizations have...
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