Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Atezolizumab plus bevacizumab remains the most widely used first-line therapy for unresectable hepatocellular carcinoma, while lenvatinib continues to be an important alternative. This international multicenter study evaluated whether...
PRISM is one of the largest prospective real-world studies evaluating systemic therapy for unresectable hepatocellular carcinoma in routine clinical practice across Japan. This analysis reports outcomes from the...
Introduction: Introduction: Atezolizumab plus bevacizumab (Atezo-Bev) is the standard first-line systemic therapy for many patients with unresectable hepatocellular carcinoma (uHCC). However, treatment success depends not only on tumor...
Introduction: Hepatocellular Carcinoma surgical resection remains a standard curative treatment for early-stage disease, but many patients are poor surgical candidates because of cirrhosis, portal hypertension, advanced age, or...
Introduction Hepatocellular Carcinoma management increasingly incorporates Immune Checkpoint Inhibitors for downstaging and bridging prior to Liver Transplantation. Although checkpoint inhibitors can successfully expand transplant eligibility and improve tumor...
Introduction Hepatocellular Carcinoma remains one of the leading causes of cancer-related mortality worldwide. Although curative-intent therapies such as liver transplantation, surgical resection and ablation can achieve durable disease...
Introduction Recurrence after curative-intent resection or ablation remains one of the greatest challenges in Hepatocellular Carcinoma management, with early relapse rates remaining high even after apparently successful treatment....
Introduction External Beam Radiation Therapy has historically played a limited role in the management of Hepatocellular Carcinoma because of concerns regarding radiation-induced liver injury and limited survival data....
Introduction Advanced Hepatocellular Carcinoma, Cholangiocarcinoma and rare primary liver cancers remain therapeutically challenging after progression on standard systemic therapy. Conventional targeted next-generation sequencing panels identify actionable alterations in...
Introduction Locoregional therapy (LRT) remains a cornerstone treatment strategy for patients with early- and intermediate-stage Hepatocellular Carcinoma. Although procedures such as transarterial chemoembolization and ablative therapies are routinely...
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