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Trending Topics in Gastroenterology

Explore current gastroenterology questions, clinical answers, and emerging research by topic.

21

Iptacopan Preserves Kidney Function in IgA Nephropathy: NEJM | August 2026

Introduction: IgA nephropathy is a progressive immune-mediated kidney disease in which alternative complement pathway activation contributes to glomerular inflammation and renal injury. Iptacopan is an oral selective complement...

22

A Steroid-Sparing Breakthrough(Obexelimab) for IgG4-Related Disease: NEJM | June 2026

Introduction: IgG4-related disease (IgG4-RD) is a chronic fibroinflammatory disorder that can affect virtually any organ. Although glucocorticoids remain the mainstay of treatment, relapse is common after tapering, and...

23

HBV Reactivation During Immunosuppressive Therapy: Alimentary Pharmacology & Therapeutics | July 2026

Introduction: Hepatitis B virus (HBV) reactivation remains a potentially serious complication of immunosuppressive and anticancer therapies. While current guidelines classify patients into high-, moderate-, and low-risk categories, this...

24

Advancing Liver Health in a Shifting Global Landscape: Nat Re Gastro & Hepatol | July 2026

Introduction: Liver disease is entering a new era. While steatotic liver disease (SLD) is rapidly becoming one of the world's leading non-communicable diseases, progress toward viral hepatitis elimination...

25

ML Predicts Response to TPE in Pediatric ALF: JCEH | July 2026

Introduction: Therapeutic plasma exchange (TPE) is increasingly used in pediatric acute liver failure (ALF), but it artificially lowers bilirubin and INR, making it difficult to determine whether a...

26

Alcohol Intake and Health Study: J of Studies on Alcohol and Drugs | July 2026

Introduction: For decades, low-to-moderate alcohol consumption has been considered by some to offer potential cardiovascular benefits. This comprehensive U.S. modeling study re-evaluated the lifetime health impact of alcohol...

27

Genetic Testing in Adult Cholestatic Liver Disease: Gut | June 2026

Introduction: Advances in genetic sequencing have transformed the understanding of cholestatic liver diseases. Conditions once considered exclusive to children are now recognized in adolescents and adults, with genetic...

28

Genetic Testing in Adult Cholestatic Liver Disease: Gut | July 2026

Introduction: Advances in genetic sequencing have transformed the understanding of cholestatic liver diseases. Conditions once considered exclusive to children are now recognized in adolescents and adults, with genetic...

29

ELF and Liver Disease: Gut | May 2026

Introduction: Early detection of advanced fibrosis in steatotic liver disease remains a major clinical challenge, particularly in individuals with type 2 diabetes and hazardous alcohol use. This real-world...

30

The Liver as a Target for Healthy Aging : Ageing Res Rev | June 2026

Introduction: Aging is a complex biological process that affects multiple organs and progressively increases vulnerability to chronic diseases. Among these organs, the liver occupies a central role in...

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