Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: The progression from metabolic dysfunction-associated fatty liver (MAFL) to metabolic dysfunction-associated steatohepatitis (MASH) is driven by complex interactions between hepatocytes and immune cells. This study identifies a...
Introduction: Cardiovascular–Kidney–Metabolic (CKM) syndrome recognizes the close interaction between obesity, type 2 diabetes, chronic kidney disease, and cardiovascular disease. This review highlights the emerging role of the gut...
Small intestinal adenocarcinoma (SIA) is a rare gastrointestinal cancer with limited disease-specific prognostic biomarkers and generally poor outcomes. This nationwide Dutch population-based study evaluated whether three routinely available...
Introduction: Metabolic dysfunction–associated steatotic liver disease (MASLD) is closely linked to insulin resistance and type 2 diabetes, with the liver traditionally viewed as a key regulator of blood...
Introduction: Pancreatic ductal adenocarcinoma (PDAC) develops through a series of precursor lesions, beginning with acinar-to-ductal metaplasia (ADM) and progressing to pancreatic intraepithelial neoplasia and invasive cancer. While genetic...
Introduction: Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of hematologic malignancies but has achieved limited success in solid tumors such as pancreatic cancer. Major barriers...
Adipose tissue is no longer viewed simply as a fat storage organ; it is now recognized as a highly active endocrine and neuro-regulatory organ that coordinates whole-body metabolism....
Introduction: Despite major advances in lipid-lowering therapy, many patients continue to experience residual cardiovascular risk, particularly those with elevated triglyceride-rich lipoproteins and mixed dyslipidemia. Angiopoietin-like protein 3 (ANGPTL3)...
Cancer cells constantly adapt to inflammatory stress generated by the immune system, particularly during immune checkpoint inhibitor therapy. This study explored whether inflammatory cytokines such as interferon-γ (IFNγ),...
Introduction: The colorectal cancer (CRC) microbiome has emerged as a key factor influencing tumor development, progression, and response to treatment. Among microbial species implicated in CRC, Fusobacterium nucleatum...
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