Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction External Beam Radiation Therapy has historically played a limited role in the management of Hepatocellular Carcinoma because of concerns regarding hepatic toxicity and limited survival data. However,...
Introduction Most patients with Hepatocellular Carcinoma present with advanced unresectable disease, limiting curative-intent treatment opportunities. Although systemic therapy remains the standard for advanced-stage HCC, modern immunotherapy-based combinations have...
Introduction Durvalumab plus Tremelimumab (STRIDE regimen) has emerged as a first-line immunotherapy option for unresectable Hepatocellular Carcinoma following the pivotal HIMALAYA trial. However, real-world evidence regarding efficacy, safety...
Introduction Chimeric antigen receptor T-cell therapy has revolutionized hematologic oncology and is increasingly being explored beyond cancer. In chronic liver disease, progressive fibrosis driven by activated hepatic stellate...
Introduction Secondary prevention of oesophageal variceal bleeding traditionally relies on combination therapy with non-selective beta-blockers and endoscopic band ligation in patients with cirrhosis. However, patients with hepatocellular carcinoma...
Introduction and Summary This commentary discusses the role of serum biomarkers in hepatocellular carcinoma surveillance, particularly after a randomised trial by Hirode et al. evaluated whether adding AFP,...
Introduction Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality in patients with cirrhosis. Despite advances in treatment, outcomes are largely determined by stage at diagnosis, making...
Introduction Hepatocellular carcinoma with portal vein tumor thrombus represents one of the most aggressive forms of liver cancer, associated with poor prognosis and limited survival. Standard treatment relies...
Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the leading cause of chronic liver disease worldwide and closely parallels the epidemics of obesity and type 2 diabetes....
Introduction Hepatocellular carcinoma remains a major global cancer burden, with high recurrence rates even after curative therapies such as resection or ablation. Historically, effective adjuvant treatments have been...
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