Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Cancer cells constantly adapt to inflammatory stress generated by the immune system, particularly during immune checkpoint inhibitor therapy. This study explored whether inflammatory cytokines such as interferon-γ (IFNγ),...
Tertiary lymphoid structures are local immune hubs within tumors, but this study shows that their mere presence is not enough; their maturation, location, and cellular organization determine biological...
CLDN18.2 is emerging as a therapeutic target in gastrointestinal cancers, but its benefit in pancreatic ductal adenocarcinoma has been limited. This study identifies a key resistance mechanism: KRAS...
The oral cavity contains the second largest microbial ecosystem in the human body and acts as a major interface between the external environment and multiple organ systems. This...
This translational study investigated whether exercise-induced changes in gut microbiota contribute to the metabolic benefits observed after Roux-en-Y gastric bypass surgery. Thirty-two women undergoing bariatric surgery were randomized...
Introduction: Chronic inflammation is the principal driver of colitis-associated cancer (CAC) in patients with long-standing ulcerative colitis (UC). Although the intestinal microbiome has long been implicated in colorectal...
Introduction: Introduction: Claudin 18.2 (CLDN18.2) has emerged as an important therapeutic target in gastrointestinal malignancies, with encouraging results in gastric and gastroesophageal cancers. Its expression in pancreatic ductal...
Introduction: Esophageal Adenocarcinoma is an aggressive malignancy strongly associated with chronic gastroesophageal reflux disease and exposure to acidic bile reflux. Despite advances in multimodal therapy, chemotherapy resistance remains...
Introduction Hypercholesterolemia remains a major driver of atherosclerotic cardiovascular disease despite the availability of statins, PCSK9 inhibitors and RNA-based therapies. Lifelong treatment adherence and incomplete LDL reduction continue...
Introduction Liver development during childhood involves dynamic metabolic, immune and stromal maturation processes that differ substantially from adult liver biology. However, most hepatic single-cell reference atlases and mechanistic...
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