Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction Hepatocellular carcinoma (HCC) outcomes are critically dependent on stage at diagnosis, with early-stage disease offering opportunities for curative therapies such as resection, ablation, or transplantation. Despite advances...
Introduction Fibrolamellar carcinoma (FLC) is a rare and biologically distinct primary liver cancer that predominantly affects adolescents and young adults without cirrhosis or other chronic liver disease. Unlike...
Introduction Transarterial chemoembolization (TACE) remains one of the most important treatments for unresectable hepatocellular carcinoma, but its clinical benefit is often limited by post-procedural liver injury. Traditionally, this...
Introduction The Barcelona Clinic Liver Cancer (BCLC) classification has remained the cornerstone for staging, prognosis, and treatment allocation in hepatocellular carcinoma for more than two decades. Its strength...
Recurrence of hepatocellular carcinoma (HCC) after liver transplantation occurs in 15–20% of patients and remains a major determinant of post-transplant survival. This international matched cohort study evaluated whether...
Introduction: The Biomarkers Used for HCC Surveillance Ultrasound (US) is the backbone of hepatocellular carcinoma (HCC) surveillance, but its sensitivity for early-stage HCC is imperfect. Blood-based biomarkers are...
Introduction Alpha-fetoprotein (AFP) remains the most widely used biomarker in hepatocellular carcinoma (HCC) surveillance. Although AFP alone is insufficient for screening, its combination with ultrasound improves early HCC...
This landmark genomic analysis presents one of the largest real-world datasets of hepatocellular carcinoma (HCC) and combined hepatocellular–cholangiocarcinoma (cHCC–CCA), encompassing 2,372 HCC and 150 mixed histology cases profiled...
The CHANCE2202 study evaluated whether combining TACE with immune checkpoint inhibitors (ICIs) plus VEGF inhibitors or TKIs improves outcomes compared to TACE alone in intermediate-stage hepatocellular carcinoma (HCC)....
Immune checkpoint inhibitor–based regimens have become central to the treatment of advanced hepatocellular carcinoma (HCC), but comparative effectiveness against tyrosine kinase inhibitors in real-world practice remains an important...
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