Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction: Individuals with Lynch syndrome (LS) require lifelong surveillance for colorectal and upper gastrointestinal cancers, yet adherence to screening recommendations remains suboptimal. This study evaluated whether a dedicated...
Introduction: Cancer-related symptoms often persist despite guideline-based pharmacologic treatment, affecting quality of life throughout the cancer journey. This review summarizes the current evidence, safety considerations, and practical implementation...
Introduction: Local ablative therapy plays an important role in managing oligometastatic liver disease when surgical resection is not feasible. This review compares stereotactic body radiotherapy (SBRT) and percutaneous...
Introduction: Borderline resectable cholangiocarcinoma (CCA) carries a poor prognosis because many patients cannot undergo curative surgery. Following the approval of gemcitabine–cisplatin–durvalumab (GCD) in advanced biliary tract cancer, this...
Introduction: Immune checkpoint inhibitors have revolutionized the treatment of dMMR/MSI-H rectal cancer, but most patients worldwide continue to receive total neoadjuvant therapy (TNT) as standard care. This international...
Introduction: Immune checkpoint inhibitors (ICIs) are the standard first-line treatment for MSI-H/dMMR metastatic colorectal cancer (mCRC). In the absence of direct head-to-head trials, this reconstructed individual patient data...
Introduction: Immune checkpoint inhibitors (ICIs) have transformed the treatment of microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR) metastatic colorectal cancer (mCRC). While pembrolizumab and nivolumab are established treatment options, recent...
Introduction: Neuroendocrine liver metastases (NELM) are a major determinant of morbidity and mortality in patients with neuroendocrine neoplasms. Over the past three decades, advances in imaging, systemic therapies,...
Introduction: Pathological complete response (pCR) following neoadjuvant therapy is considered a favorable prognostic marker in esophageal adenocarcinoma. However, whether patients achieving pCR derive similar long-term benefit regardless of...
Introduction: Circulating tumor DNA (ctDNA) has emerged as a promising noninvasive biomarker for monitoring treatment response and residual disease in solid tumors. However, its prognostic value during neoadjuvant...
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