Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction Chronic Pancreatitis is a well-established risk factor for Pancreatic Ductal Adenocarcinoma, particularly in hereditary pancreatitis syndromes where lifetime cancer risk is markedly elevated. However, the biologic mechanisms...
Introduction Hypoxia-Inducible Factor 1-alpha is a master regulator of cellular adaptation to hypoxia, coordinating metabolic reprogramming, angiogenesis and stress responses. Although transient HIF-1α activation is protective during acute...
Introduction Programmed Cell Death Protein 1 blockade has revolutionized cancer immunotherapy, yet the precise spatial and temporal mechanisms by which PD-1 suppresses T-cell activation remain incompletely understood. Although...
Introduction Autophagy is a highly conserved cellular homeostatic mechanism that enables recycling of intracellular components, removal of damaged organelles and adaptation to metabolic stress. In cancer biology, autophagy...
Introduction Liver Fibrosis results from persistent hepatic injury, chronic inflammation and activation of hepatic stellate cells (HSCs). Chemokine-mediated immune recruitment is central to fibrogenesis, yet many inflammatory pathways...
Introduction Intrahepatic Cholangiocarcinoma is characterised by a highly desmoplastic and immunosuppressive tumour microenvironment (TME), contributing to poor responsiveness to systemic therapies and immune checkpoint inhibitors. While T-cell biology...
Introduction Metabolic Dysfunction-Associated Steatohepatitis is increasingly recognized as a multisystem disorder involving complex interactions between metabolism, intestinal microbiota, immune activation and fibrosis. Although gut dysbiosis has long been...
Introduction Intestinal fibrosis is a major complication of Crohn’s Disease and remains a leading cause of bowel strictures, obstruction and repeated surgery. Current anti-inflammatory therapies have limited efficacy...
Introduction Early-life environmental and immunologic exposures are increasingly implicated in the pathogenesis of Inflammatory bowel disease. Altered neonatal microbiota, elevated fecal calprotectin and immune dysregulation have previously been...
Introduction Germline CTNNA1 variants have emerged as an important cause of hereditary diffuse gastric cancer (HDGC), yet their clinical penetrance, disease spectrum and biological mechanisms have remained poorly...
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