Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction Antibody–drug conjugates (ADCs) have transformed oncology by enabling selective delivery of potent cytotoxic agents directly to tumor cells. Recent successes, particularly with trastuzumab deruxtecan, have expanded the...
Introduction Natural killer (NK) cell–based immunotherapy has emerged as a promising strategy in cancer treatment because of its ability to mediate tumor killing without prior antigen sensitization. However,...
Introduction Ageing is typically associated with declining immune function (immunosenescence) and chronic low-grade inflammation (inflammageing), leading to increased susceptibility to infections, cancer, and metabolic diseases. However, centenarians—individuals aged...
Introduction and Summary Pancreatic ductal adenocarcinoma remains one of the most immunotherapy-resistant gastrointestinal cancers. A major reason is its dense, immunologically “cold” tumour microenvironment, where cytotoxic T cells...
Introduction Inflammatory bowel disease is increasingly understood as a disorder shaped not only by the gut itself, but also by extraintestinal immune and microbial influences. The oral cavity...
Introduction The gastrointestinal tract functions as a highly integrated system where digestion, immunity, and metabolic regulation are closely linked to the gut microbiota. This vast microbial ecosystem plays...
Introduction Undernutrition remains a major global health challenge, particularly in low-resource settings, and is closely linked to a complex gut disorder known as environmental enteropathy (EE). EE is...
Introduction Dengue continues to emerge as a major global public health challenge, driven by rapid urbanisation, climate change, and the expansion of mosquito habitats. Conventional vector-control strategies such...
Introduction Advanced primary liver cancers, including hepatocellular carcinoma and cholangiocarcinoma, remain difficult to treat once they become refractory to standard systemic therapies. Survival outcomes are poor, and therapeutic...
Introduction Cholestatic liver disease (CLD) is a progressive condition characterised by impaired bile formation and flow, leading to bile accumulation, liver injury, and eventual cirrhosis or liver failure....
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