Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Obesity is no longer viewed only as a metabolic disorder; it is now a major cancer-promoting state. This review explains how excess adiposity drives cancer through intertwined biologic...
Introduction Gastric cancer remains one of the most lethal malignancies worldwide. The tumour microenvironment (TME)—particularly cancer-associated fibroblasts (CAFs)—plays a critical role in tumour progression, immune evasion, and resistance...
Introduction Most obesity therapies reduce body fat, but they also cause a meaningful loss of lean mass, including skeletal muscle. This matters because preserving muscle is important for...
Chromosome 8q amplification, a common genomic alteration in hepatocellular carcinoma (HCC), includes the gene TATA-box binding protein–associated factor 2 (TAF2), a key component of the TFIID basal transcription...
Introduction Understanding which genes restrain gastric tumor growth—and how host factors like Helicobacter pylori shape tumor biology—remains central to precision prevention and therapy. CRISPR-Cas9 loss-of-function screening offers a...
Introduction Most clinicians recognise classic inherited polyposis syndromes such as familial adenomatous polyposis (FAP) from pathogenic variants in APC, and MUTYH-associated polyposis (MAP) from biallelic MUTYH variants. Yet,...
Introduction Acute-on-chronic liver failure (ACLF) is a highly dynamic and life-threatening syndrome marked by intense systemic inflammation and immune dysregulation. In Asia, hepatitis B virus (HBV) reactivation is...
Introduction UGT1A1 poor metabolisers (PMs) are at higher risk of severe irinotecan-related toxicity. A 30% upfront dose reduction is commonly recommended for safety, but whether this compromises survival...
Porto-sinusoidal vascular disorder (PSVD) is a rare, non-cirrhotic vascular liver disease characterised by portal venule and sinusoidal abnormalities leading to portal hypertension. Despite its clinical significance, the underlying...
Glucagon-like peptide-1 (GLP-1) receptor agonists have evolved from glucose-lowering agents for type 2 diabetes into transformative therapies reshaping cardiometabolic medicine. In this comprehensive review, Daniel Drucker outlines how...
We are pioneers in clinical intelligence, dedicated to helping gastroenterologists harness the power of artificial intelligence to drive precision, efficiency, and patient growth.