Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction Colorectal Liver Metastases frequently recur despite curative-intent surgery, with nearly half of patients developing relapse within the first postoperative year. Early identification of biologically aggressive disease remains...
Introduction Colorectal Liver Metastases have historically been considered a contraindication to Liver Transplantation because of high recurrence risk and limited organ availability. However, modern systemic therapies, refined biologic...
Introduction Antibody-Drug Conjugate development has rapidly transformed treatment paradigms for HER2-expressing malignancies. However, resistance, heterogeneous HER2 expression and toxicity remain major limitations of currently available HER2-targeted therapies. TQB2102...
Introduction Recurrence after curative-intent surgery for Colorectal Liver Metastases remains common, particularly in patients with high metastatic burden. The liver represents the dominant site of relapse, even after...
Introduction The concept of oligometastatic disease proposes that selected patients with limited metastatic burden may benefit from aggressive local treatment directed at metastatic sites in addition to systemic...
Introduction Perioperative chemotherapy remains the standard treatment approach for locally advanced resectable gastric and gastroesophageal junction (GEJ) adenocarcinoma. However, recurrence rates remain high despite curative-intent surgery and systemic...
Introduction Regular physical activity is generally associated with reduced colorectal cancer (CRC) risk. However, extreme endurance exercise may produce repetitive gastrointestinal stress through splanchnic hypoperfusion, ischemia–reperfusion injury, mucosal...
Introduction Recent FDA approvals continue to accelerate the shift toward biomarker-driven and targeted cancer therapy across hematologic malignancies and solid tumors. Novel immunotherapies and molecularly targeted agents are...
Introduction Immune checkpoint inhibitors targeting programmed cell death protein-(ligand) 1 (PD-[L]1) have transformed first-line treatment of advanced gastric cancer (GC) and gastroesophageal junction cancer (GEJC). However, important regional...
Introduction Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human malignancies, characterized by aggressive tumor biology, late-stage diagnosis and limited long-term survival. Despite decades of therapeutic...
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