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Getting IEC and CDSCO Approval for Gastroenterology Clinical Trials in India: A Step-by-Step Guide

Getting IEC and CDSCO Approval for Gastroenterology Clinical Trials in India: A Step-by-Step Guide

You have a well-designed gastroenterology trial - a prospective cohort comparing fecal microbiota transplantation protocols in recurrent Clostridioides difficile, or a phase II drug trial in refractory IBD. The science is solid. The question everyone asks next is the one nobody teaches in fellowship: How do you actually get this approved in India? This guide walks through the IEC and CDSCO process for gastroenterology clinical trials - what to submit, in what order, and where most investigators lose months they could have saved.

April 16, 2026•GastroAGI Team
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Top Gastroenterology Conferences in India: ISGCON, INASL, SGEI & WCOG 2026

Top Gastroenterology Conferences in India: ISGCON, INASL, SGEI & WCOG 2026

A DM physician at a tier-2 hospital spends hours each week parsing conflicting treatment protocols for NAFLD — one from a US guideline body, another from a European liver society. Neither accounts for Indian dietary patterns, genetic predispositions, or the public-health context of a country carrying nearly 20% of the world's chronic liver disease burden. The answer, most of the time, isn't in a journal — it's on a conference floor in Varanasi, Amritsar, or New Delhi, where Indian gastroenterologists are producing and debating exactly that evidence. This post maps every major national conference where that work happens.

April 15, 2026•GastroAGI Team
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Fatigue in Aging: When to Stop Reassuring and Start Investigating

Fatigue in Aging: When to Stop Reassuring and Start Investigating

Fatigue in older adults is one of the most dismissed symptoms in medicine — and one of the most dangerous to ignore. Nearly one-third of people over 65 report significant fatigue, yet it's routinely chalked up to "just getting older." That assumption costs people years of quality life.Persistent fatigue is a signal, not a sentence. The biological mechanisms driving exhaustion in aging are increasingly well-understood — and many are treatable. Understanding where to draw the line between normal tiredness and a symptom worth pursuing starts at the cellular level.

April 14, 2026•GastroAGI Team
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Why the 6-Month Rule No Longer Holds Up | Early Liver Transplantation for Alcoholic Hepatitis:

Why the 6-Month Rule No Longer Holds Up | Early Liver Transplantation for Alcoholic Hepatitis:

A 34-year-old woman with no prior liver disease presents with her first episode of severe alcoholic hepatitis — Maddrey's Discriminant Function of 68, MELD 28, non-responsive to corticosteroids at day 7. Her family is engaged, she has no prior treatment history, and she is asking the right questions. Your medical options are effectively exhausted. She will likely be dead in weeks. The question is not whether she deserves a transplant. The question is whether a number - six months - should decide that for you.

April 9, 2026•GastroAGI Team
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(2026 Updated) Acute Pancreatitis in 2026: Predicting Severity, Timing Intervention, and Avoiding Common Pitfalls

(2026 Updated) Acute Pancreatitis in 2026: Predicting Severity, Timing Intervention, and Avoiding Common Pitfalls

A 58-year-old woman is admitted with her first episode of acute pancreatitis. Gallstones are the cause. Her initial SIRS criteria are met on two counts, and her creatinine is creeping up. She looks uncomfortable but not critically ill. The question isn't whether she has pancreatitis — it's whether she's about to declare severe disease, whether you should be scanning her now, and whether she'll need a drain or an OR before this admission ends. That decision tree is what this post is built around.

April 7, 2026•GastroAGI Team
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ACLF vs ALF: How to Tell Them Apart and Why It Changes Everything About Treatment

ACLF vs ALF: How to Tell Them Apart and Why It Changes Everything About Treatment

A 58-year-old man with known alcohol-related cirrhosis is admitted with jaundice, confusion, and a bilirubin of 18 mg/dL. Three beds down, a 24-year-old woman with no liver history presents with the same triad — jaundice, encephalopathy, bilirubin of 22 mg/dL — after two weeks of paracetamol overuse. Both patients look critically unwell. Both will be labelled "liver failure" in the initial clerking note. But the diagnosis, prognosis, and management for these two patients are so fundamentally different that conflating them is one of the more consequential errors in hepatology.The distinction between acute-on-chronic liver failure and acute liver failure matters not just academically but at every decision point: who gets admitted to the ICU, who gets listed for transplant, which vasopressors are appropriate, how long you wait before escalating. The challenge is that on a busy admissions ward, the two can look identical for the first few hours. Both present with jaundice, encephalopathy, and coagulopathy. Both can deteriorate within 24 hours. And the underlying liver disease in ACLF may never have been formally diagnosed before. This post is specifically about the diagnostic framework that separates them — and what changes downstream once you get it right.

April 6, 2026•GastroAGI Team
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