Trending Topics in Gastroenterology
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Explore current gastroenterology questions, clinical answers, and emerging research by topic.
Introduction KRAS G12C mutations represent a clinically important molecular subtype of metastatic colorectal cancer (mCRC), occurring in approximately 3–4% of cases and often associated with aggressive disease biology...
Introduction Precision oncology has transformed cancer care through the integration of genomic profiling and targeted therapies. However, translating complex next-generation sequencing data into clinically actionable treatment strategies remains...
Introduction Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited survival gains despite advances in systemic therapy. More than 90% of PDAC tumors harbor...
Introduction Pregnancy-associated cancers (PACs), defined as malignancies diagnosed during pregnancy or within the first postpartum year, represent a growing and highly complex clinical challenge. Management requires balancing timely...
Introduction Gastric cancer with extensive lymph node metastasis carries a poor prognosis and presents major challenges in surgical management. In Japan, neoadjuvant chemotherapy followed by D2 gastrectomy with...
Introduction Modern oncology care depends on rapid interpretation of increasingly complex pathology reports that integrate histopathology, immunohistochemistry and molecular profiling. Synthesizing these data into concise, clinically usable summaries...
Introduction Thymidylate synthase inhibition remains a central therapeutic strategy in colorectal cancer, most commonly achieved with fluoropyrimidines such as 5-fluorouracil (5-FU). Raltitrexed, a direct thymidylate synthase inhibitor, was...
Introduction KRAS remains the dominant oncogenic driver in pancreatic ductal adenocarcinoma (PDAC), yet therapeutic targeting of KRAS has produced only modest and often short-lived responses due to rapid...
Introduction Locally advanced pancreatic cancer (LAPC) remains a highly lethal disease with limited therapeutic options and poor long-term survival. For patients who remain unresectable after induction chemotherapy, local...
Introduction Colorectal cancer (CRC) remains the third most commonly diagnosed cancer and the second leading cause of cancer-related mortality worldwide. Although CRC has historically been concentrated in Western...
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